Stem cells for the treatment of cardiovascular diseases. An update

Jorge Bartolucci Johnston, Fernando J. Verdugo, Ricardo Larrea, Flavio Carrión, Rubén Lamich, Pablo Pedreros, Manuel Delgado, Patricio Sanhueza, Maroun Khoury, Fernando E. Figueroa

Research output: Contribution to journalScientific reviewpeer-review

3 Scopus citations

Abstract

All rights reserved. Available medical therapy is unable to completely prevent or revert the pathological cardiac remodeling secondary to ischemia or other injuries, which is responsible for the development of heart failure. Regenerative medicine through stem cells had an explosive development in the cardiovascular area during the past decade. Stem cells possess the capacity to regenerate, repair or substitute damaged tissue, allowing the reestablishment of its function. Stem cells can also modulate apoptosis, angiogenesis, fibrosis and inflammation, favoring the endogenous regenerative process initiated by the damaged tissue. These capacities have been corroborated in several animal models of cardiovascular diseases with positive results. In humans, therapies with bone marrow mononuclear stem cells, mesenchymal stem cells and cardiac stem cells are safe. Most randomized clinical trials in patients with myocardial infarction or cardiomyopathies of different etiologies have reported benefits on ventricular function, quality of life and even over mortality of treated patients. This article reviews the state of art of stem cell therapy in cardiovascular diseases, focusing on the most common cellular types used in patients with acute myocardial infarction and chronic cardiomyopathies of different etiologies.
Original languageAmerican English
Pages (from-to)1034-1046
Number of pages13
JournalRevista Medica de Chile
Volume142
Issue number8
DOIs
StatePublished - 1 Jan 2014

Keywords

  • Cardiomyopathies
  • Myocardial infaction
  • Stem Cell Transplantation
  • Ventricular remodeling

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