Short-term effects of 2% atorvastatin dentifrice as an adjunct to periodontal therapy: A randomized double-masked clinical trial

David Rosenberg*, Catherine X. Andrade, Alejandra Chaparro, Carolina Inostroza Silva, Valeria Ramírez, Déborah Violant, José Narti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Background: The pleiotropic effects of statins, such as immunomodulation and anti-inflammatory effects, may also improve periodontal conditions. The aim of the present study is to assess the effectiveness of a dentifrice medicated with 2% atorvastatin in improving clinical periodontal parameters as a complement to non-surgical periodontal treatment (NSPT). Methods: A randomized, double-masked clinical trial was performed with two parallel groups: 1) atorvastatin group (NSPT plus medicated 2% atorvastatin dentifrice) and 2) placebo group (NSPT plus placebo dentifrice). The effectiveness of these treatments was assessed using periodontal measurements obtained at baseline and 1 month later. The measurements were probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI), and periodontal inflamed surface area (PISA). Multiple linear regression models were used to compare outcome variables after adjusting for sex, diabetes, and tobacco use. Results: A total of 36 individuals participated in this study (atorvastatin group, n = 18; placebo group, n = 18). Both groups showed improvements in periodontal parameters. The atorvastatin group showed a decrease of 297.63 mm2 in PISA (95% confidence interval = 76.04 to 519.23; P = 0.01), which was significantly greater than the reduction observed in the placebo group. There was also a significantly greater reduction in mean PD, percentage of sites with PD ≥5 mm, mean CAL, percentage of sites with CAL ≥5 mm, BOP, and GI in the atorvastatin group compared with the placebo group. Conclusion: NSPT plus 2% atorvastatin medicated dentifrice was more effective in improving clinical periodontal parameters than NSPT plus a placebo dentifrice.

Original languageEnglish
Pages (from-to)623-630
Number of pages8
JournalJournal of Periodontology
Issue number5
StatePublished - 1 May 2015

Bibliographical note

Publisher Copyright:
© 2015, American Academy of Periodontology. All rights reserved.


  • Chronic periodontitis
  • Clinical trial
  • Dentifrices


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