SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder

Valeria Salinas; Juana Villarroel; Hernán Silva; Luisa Herrera; Sonia Jerez; Alejandra Zazueta; Cristián Montes; Rodrigo Nieto; M. Leonor Bustamante

doi:10.1186/s13104-020-4924-6

SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder

Valeria Salinas, Juana Villarroel, Hernán Silva, Luisa Herrera, Sonia Jerez, Alejandra Zazueta, Cristián Montes, Rodrigo Nieto, M. Leonor Bustamante^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objective: Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene. Results: We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.

Original language	English
Article number	61
Journal	BMC Research Notes
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s13104-020-4924-6
State	Published - 7 Feb 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Author(s).

Keywords

5HTTLPR
Five-factor model
Gene interaction
Genetics
Personality

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10.1186/s13104-020-4924-6

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title = "SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder",

abstract = "Objective: Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene. Results: We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.",

keywords = "5HTTLPR, Five-factor model, Gene interaction, Genetics, Personality",

author = "Valeria Salinas and Juana Villarroel and Hern{\'a}n Silva and Luisa Herrera and Sonia Jerez and Alejandra Zazueta and Cristi{\'a}n Montes and Rodrigo Nieto and Bustamante, {M. Leonor}",

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doi = "10.1186/s13104-020-4924-6",

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T1 - SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder

AU - Salinas, Valeria

AU - Villarroel, Juana

AU - Silva, Hernán

AU - Herrera, Luisa

AU - Jerez, Sonia

AU - Zazueta, Alejandra

AU - Montes, Cristián

AU - Nieto, Rodrigo

AU - Bustamante, M. Leonor

PY - 2020/2/7

Y1 - 2020/2/7

N2 - Objective: Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene. Results: We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.

AB - Objective: Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene. Results: We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.

KW - 5HTTLPR

KW - Five-factor model

KW - Gene interaction

KW - Genetics

KW - Personality

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SN - 1756-0500

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JO - BMC Research Notes

JF - BMC Research Notes

IS - 1

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ER -

SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder

Abstract

Bibliographical note

Keywords

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