Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide

Gino Nardocci; Aldo Martin; Sebastián Abarzúa; Jorge Rodríguez; Felipe Simon; Edison P. Reyes; Claudio Acuña-Castillo; Cristina Navarro; Paula P. Cortes; Ricardo Fernández

doi:10.1016/j.jneuroim.2014.12.002

Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide

Gino Nardocci, Aldo Martin, Sebastián Abarzúa, Jorge Rodríguez, Felipe Simon, Edison P. Reyes, Claudio Acuña-Castillo, Cristina Navarro, Paula P. Cortes, Ricardo Fernández^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90. min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.

Original language	English
Pages (from-to)	44-52
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	278
DOIs	https://doi.org/10.1016/j.jneuroim.2014.12.002
State	Published - 15 Jan 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Elsevier B.V.

Keywords

Bilateral carotid/sinus neurotomy
Carotid body
Epinephrine
Glucocorticoids
Multiple organ dysfunction
Sepsis
TNF-α
Tissue damage

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title = "Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide",

abstract = "Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90. min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.",

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author = "Gino Nardocci and Aldo Martin and Sebasti{\'a}n Abarz{\'u}a and Jorge Rodr{\'i}guez and Felipe Simon and Reyes, {Edison P.} and Claudio Acu{\~n}a-Castillo and Cristina Navarro and Cortes, {Paula P.} and Ricardo Fern{\'a}ndez",

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AU - Nardocci, Gino

AU - Martin, Aldo

AU - Abarzúa, Sebastián

AU - Rodríguez, Jorge

AU - Simon, Felipe

AU - Reyes, Edison P.

AU - Acuña-Castillo, Claudio

AU - Navarro, Cristina

AU - Cortes, Paula P.

AU - Fernández, Ricardo

PY - 2015/1/15

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N2 - Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90. min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.

AB - Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90. min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.

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KW - Epinephrine

KW - Glucocorticoids

KW - Multiple organ dysfunction

KW - Sepsis

KW - TNF-α

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ER -

Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide

Abstract

Bibliographical note

Keywords

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