Sepsis progression to multiple organ dysfunction in carotid chemo/baro-denervated rats treated with lipopolysaccharide

Gino Nardocci, Aldo Martin, Sebastián Abarzúa, Jorge Rodríguez, Felipe Simon, Edison P. Reyes, Claudio Acuña-Castillo, Cristina Navarro, Paula P. Cortes, Ricardo Fernández*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Sepsis progresses to multiple organ dysfunction (MOD) due to the uncontrolled release of inflammatory mediators. Carotid chemo/baro-receptors could play a protective role during sepsis. In anesthetized male rats, we measured cardiorespiratory variables and plasma TNF-α, glucocorticoids, epinephrine, and MOD marker levels 90. min after lipopolysaccharide (LPS) administration in control (SHAM surgery) and bilateral carotid chemo/baro-denervated (BCN) rats. BCN prior to LPS blunted the tachypneic response and enhanced tachycardia and hypotension. BCN-LPS rats also showed blunted plasma glucocorticoid responses, boosted epinephrine and TNF-α responses, and earlier MOD onset with a lower survival time compared with SHAM-LPS rats. Consequently, the complete absence of carotid chemo/baro-sensory function modified the neural, endocrine and inflammatory responses to sepsis. Thus, carotid chemo/baro-receptors play a protective role in sepsis.

Original languageEnglish
Pages (from-to)44-52
Number of pages9
JournalJournal of Neuroimmunology
StatePublished - 15 Jan 2015
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by research grants from the Fondo Nacional de Desarrollo Científico y Tecnológico [FONDECYT 1120976 (RF), 1110734 (CAC), 3140414 (GN) and 1121078 (FS)], Dirección General de Investigación, Universidad Andrés Bello [UNAB DI-354-13/R (RF)], and the Millenium Institute on Immunology and Immunotherapy [ P09-016-F (FS)]. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2014 Elsevier B.V.


  • Bilateral carotid/sinus neurotomy
  • Carotid body
  • Epinephrine
  • Glucocorticoids
  • Multiple organ dysfunction
  • Sepsis
  • TNF-α
  • Tissue damage


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