TY - JOUR
T1 - Saliva sample for the massive screening of SARS-CoV-2 infection
T2 - a systematic review
AU - González Cañete, Martín
AU - Mujica Valenzuela, Isidora
AU - Carvajal Garcés, Patricia
AU - Castro Massó, Isabel
AU - González, María Julieta
AU - González-Providell, Sergio
N1 - © 2021 Elsevier Inc.
PY - 2021/5
Y1 - 2021/5
N2 - Objective: This systematic review aims to describe the value of saliva as a noninvasive sample for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in comparison with the current method for sample collection, the nasopharyngeal swab. Study Design: We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. We searched in 5 databases (PubMed, Cochrane, EBSCO, Elsevier, and MEDLINE) and included articles published between December 2019 and July 2020. Results: This review included 22 publications that met inclusion criteria, 17 of which were case series, 2 of which were case reports, and 3 of which were massive screenings. All articles compared saliva with nasopharyngeal swabs. The detection rate of SARS-CoV-2 in saliva was similar to that for nasopharyngeal swabs. The sensitivity ranged between 20% and 97%, and specificity ranged between 66% and 100%. Conclusions: This systematic review found that saliva might be an appropriate, fast, painless, simple, and noninvasive sample for SARS-CoV-2 detection, making it ideal for massive screening of SARS-CoV-2 infection.
AB - Objective: This systematic review aims to describe the value of saliva as a noninvasive sample for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in comparison with the current method for sample collection, the nasopharyngeal swab. Study Design: We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. We searched in 5 databases (PubMed, Cochrane, EBSCO, Elsevier, and MEDLINE) and included articles published between December 2019 and July 2020. Results: This review included 22 publications that met inclusion criteria, 17 of which were case series, 2 of which were case reports, and 3 of which were massive screenings. All articles compared saliva with nasopharyngeal swabs. The detection rate of SARS-CoV-2 in saliva was similar to that for nasopharyngeal swabs. The sensitivity ranged between 20% and 97%, and specificity ranged between 66% and 100%. Conclusions: This systematic review found that saliva might be an appropriate, fast, painless, simple, and noninvasive sample for SARS-CoV-2 detection, making it ideal for massive screening of SARS-CoV-2 infection.
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85101424260&origin=resultslist&sort=plf-f&src=s&sid=6060351df86d3d1eeb8c565006be55b2&sot=b&sdt=b&s=TITLE-ABS-KEY%28Saliva+sample+for+the+massive+screening+of+SARS-CoV-2+infection%3A+a+systematic+review%29&sl=99&sessionSearchId=6060351df86d3d1eeb8c565006be55b2&relpos=0
U2 - 10.1016/j.oooo.2021.01.028
DO - 10.1016/j.oooo.2021.01.028
M3 - Article
SN - 2212-4403
VL - 131
SP - 540
EP - 548
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 5
ER -