Role of microRNA Shuttled in Small Extracellular Vesicles Derived From Mesenchymal Stem/Stromal Cells for Osteoarticular Disease Treatment

Eliana Lara-Barba, María Jesús Araya, Charlotte Nicole Hill, Felipe A. Bustamante-Barrientos, Alexander Ortloff, Cynthia García, Felipe Galvez-Jiron, Carolina Pradenas, Noymar Luque-Campos, Gabriela Maita, Roberto Elizondo-Vega, Farida Djouad, Ana María Vega-Letter*, Patricia Luz-Crawford

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Osteoarticular diseases (OD), such as rheumatoid arthritis (RA) and osteoarthritis (OA) are chronic autoimmune/inflammatory and age-related diseases that affect the joints and other organs for which the current therapies are not effective. Cell therapy using mesenchymal stem/stromal cells (MSCs) is an alternative treatment due to their immunomodulatory and tissue differentiation capacity. Several experimental studies in numerous diseases have demonstrated the MSCs’ therapeutic effects. However, MSCs have shown heterogeneity, instability of stemness and differentiation capacities, limited homing ability, and various adverse responses such as abnormal differentiation and tumor formation. Recently, acellular therapy based on MSC secreted factors has raised the attention of several studies. It has been shown that molecules embedded in extracellular vesicles (EVs) derived from MSCs, particularly those from the small fraction enriched in exosomes (sEVs), effectively mimic their impact in target cells. The biological effects of sEVs critically depend on their cargo, where sEVs-embedded microRNAs (miRNAs) are particularly relevant due to their crucial role in gene expression regulation. Therefore, in this review, we will focus on the effect of sEVs derived from MSCs and their miRNA cargo on target cells associated with the pathology of RA and OA and their potential therapeutic impact.

Original languageEnglish
Article number768771
JournalFrontiers in Immunology
Volume12
DOIs
StatePublished - 1 Nov 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Lara-Barba, Araya, Hill, Bustamante-Barrientos, Ortloff, García, Galvez-Jiron, Pradenas, Luque-Campos, Maita, Elizondo-Vega, Djouad, Vega-Letter and Luz-Crawford.

Keywords

  • mesenchymal stem cells
  • microRNA
  • osteoarthritis
  • rheumatoid arthritis
  • small extracellular vesicles

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