RNAi therapeutics: Current status of nanoncologic siRNA delivery systems

Y. N. Cho, J. S. Brumbach, Murugan Ramalingam, Z. S. Haidar

Research output: Contribution to journalScientific reviewpeer-review

4 Scopus citations

Abstract

With the growing comprehensive understanding of antisense gene silencing and the mechanism of RNA interference (RNAi), small interfering RNA (siRNA) has gained tremendous attention as a putative therapeutic agent for cancer therapy and other diseases. Due to its inherent target specificity, siRNA has the potential to inhibit tumor cell proliferation, metastasis and retard tumor growth, all-the-while avoiding off-target and adverse effects that are commonly observed with conventional anti-cancer drugs. There are a few ongoing clinical trials using siRNA for cancer treatment and other diseases. However, to date, none have been approved by FDA. Crucial for clinical success, delivery reagents that promote cellular uptake of the siRNA, maintain its stability in the presence of nucleases and prevent potential immunogenicity in vivo are required. Therefore, in recent years, a wide range of siRNA delivery systems have been developed and evaluated. In this review, we describe the major strategies currently employed for siRNA delivery followed by a presentation of the most recent works using such a variety of delivery systems and carriers in different cancers.
Original languageAmerican English
Pages (from-to)1-17
Number of pages17
JournalJournal of Bionanoscience
Volume5
Issue number1
DOIs
StatePublished - 1 Jun 2011
Externally publishedYes

Keywords

  • Cancer
  • Delivery System
  • Liposome
  • Nanocarrier
  • Nanoncology
  • Nanoparticle
  • Non-Viral Vector
  • Polymer
  • RNAi
  • Small Interfering RNA (siRNA)

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