RNAi in arthritis: Prospects of a future antisense therapy in inflammation

Maroun Khoury, Christian Jorgensen, Florence Apparailly

Research output: Contribution to journalScientific reviewpeer-review

12 Scopus citations

Abstract

Rheumatoid arthritis is a chronic autoimmune disease of unknown etiology that is characterized by chronic systemic inflammation, mainly affecting the joints, leading to subsequent destruction of the cartilage and bone. RNA interference (RNAi) has been used as a remarkable new research tool to control gene expression and is ultimately envisioned to be useful in clinical treatments. The potential application of RNAi-based therapy in rheumatoid disorders is evaluated. The first successful attempts at TNFalpha silencing by local and systemic delivery of small interfering RNA in experimental arthritic models are discussed. In addition, RNAi and current biotherapies used in the clinic are compared and contrasted.
Original languageAmerican English
Pages (from-to)483-489
Number of pages7
JournalCurrent Opinion in Molecular Therapeutics
Volume9
Issue number5
StatePublished - 22 Oct 2007
Externally publishedYes

Keywords

  • Biotherapy
  • Inflammation
  • Rheumatoid arthritis
  • RNA interference
  • TNFα

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