Risk of infections associated with the use of biological medications; a review: Revisión panorámica

María Pilar Gambra, Juan José Montesinos, María Teresa Valenzuela Bravo, Marcela Eliana Cárcamo, C. H. Gabriel Cavada

Research output: Contribution to journalArticlepeer-review

Abstract

Biological medications are effective for the treatment of cancer and inflammatory diseases. The aim of this review is to summarize the available evidence in systematic reviews or meta-analyses about the risk of infection in patients with cancer, arthritis, psoriasis and inflammatory bowel disease who use biological medications. We included systematic reviews or meta-analyses of controlled clinical trials and case/control studies that analyze infections during and after treatment with FDA-approved biological medications for the treatment of cancer, arthritis, inflammatory bowel disease and psoriasis, both in adults and children. The following databases were consulted: PubMed, Epistemonikos, Crochrane reviews, JIB, and Prospero. A quality guideline (AMSTAR) was applied to the selected studies. We included 26 studies. The risk of infections in patients with solid organ cancer is consistent in the literature. In psoriasis there is a risk of non-serious infections. In arthritis and other inflammatory diseases there is a risk of serious infections. In inflammatory bowel disease there is a risk for opportunistic infections. In conclusion, in patients with cancer and inflammatory diseases use biological medications entails a risk of infection. The evidence is different depending on the underlying disease of each patient.

Translated title of the contributionRisk of infections associated with the use of biological medications; a review
Original languageSpanish
Pages (from-to)1155-1170
Number of pages16
JournalRevista Medica de Chile
Volume148
Issue number8
DOIs
StatePublished - Aug 2020

Bibliographical note

Publisher Copyright:
© 2020 Sociedad Medica de Santiago. All rights reserved.

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