Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Cases

Claudia Brizuela; Gastón Meza; Maroun Khoury

doi:10.1016/j.joen.2024.02.012

Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Cases

Claudia Brizuela^*, Gastón Meza, Maroun Khoury

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Introduction: Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth. Methods: Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis. Results: After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization. Conclusions: This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios.

Original language	English
Pages (from-to)	596-601
Number of pages	6
Journal	Journal of Endodontics
Volume	50
Issue number	5
DOIs	https://doi.org/10.1016/j.joen.2024.02.012
State	Published - May 2024

Bibliographical note

Publisher Copyright:
© 2024 American Association of Endodontists

Keywords

Apical periodontitis
mature teeth
mesenchymal stem cell transplantation
platelet-poor plasma
regenerative medicine

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10.1016/j.joen.2024.02.012

Cite this

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title = "Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Cases",

abstract = "Introduction: Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth. Methods: Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis. Results: After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization. Conclusions: This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios.",

keywords = "Apical periodontitis, mature teeth, mesenchymal stem cell transplantation, platelet-poor plasma, regenerative medicine",

author = "Claudia Brizuela and Gast{\'o}n Meza and Maroun Khoury",

note = "Publisher Copyright: {\textcopyright} 2024 American Association of Endodontists",

year = "2024",

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doi = "10.1016/j.joen.2024.02.012",

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AU - Khoury, Maroun

PY - 2024/5

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AB - Introduction: Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth. Methods: Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis. Results: After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization. Conclusions: This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios.

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Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth With Closed Apices and Apical Lesions: A Report of Two Cases

Abstract

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Keywords

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