1 Scopus citations


Introduction: Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth. Methods: Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis. Results: After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization. Conclusions: This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios.

Original languageEnglish
Pages (from-to)596-601
Number of pages6
JournalJournal of Endodontics
Issue number5
StatePublished - May 2024

Bibliographical note

Publisher Copyright:
© 2024 American Association of Endodontists


  • Apical periodontitis
  • mature teeth
  • mesenchymal stem cell transplantation
  • platelet-poor plasma
  • regenerative medicine


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