Retinoic acid in the immune system

Karina Pino-Lagos, Micah J. Benson, Randolph J. Noelle

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

75 Scopus citations

Abstract

On occasion, emerging scientific fields intersect and great discoveries result. In the last decade, the discovery of regulatory T cells (T®) in immunity has revolutionized our understanding of how the immune system is controlled. Intersecting the rapidly emerging field of T® function, has been the discovery that retinoic acid (RA) controls both the homing and differentiation of T®. Instantly, the wealth and breadth of knowledge of the molecular basis for RA action, its receptors, and how it controls cellular differentiation can and will be exploited to understand its profound effects on T®. Historically, vitamin A deprivation and repletion and RA agonists have been shown to profoundly affect immunity. Now these findings can be interpreted in light of the revelations that RA controls leukocyte homing and T® function.

Original languageEnglish
Title of host publicationThe Year in Immunology 2008
PublisherBlackwell Publishing Inc.
Pages170-187
Number of pages18
ISBN (Print)9781573317290
DOIs
StatePublished - Nov 2008
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1143
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Immune system
  • Retinoic acid
  • Tolerance
  • Vitamin A

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