Retinoic acid: A key player in immunity

Karina Pino-Lagos; Yanxia Guo; Randolph J. Noelle

doi:10.1002/biof.117

Retinoic acid: A key player in immunity

Karina Pino-Lagos, Yanxia Guo, Randolph J. Noelle^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

For the past 100 years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment.

Original language	English
Pages (from-to)	430-436
Number of pages	7
Journal	BioFactors
Volume	36
Issue number	6
DOIs	https://doi.org/10.1002/biof.117
State	Published - Nov 2010
Externally published	Yes

Keywords

Inflammation
Retinoic acid
Vitamin A

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/biof.117

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abstract = "For the past 100 years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment.",

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AU - Guo, Yanxia

AU - Noelle, Randolph J.

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AB - For the past 100 years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment.

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KW - Retinoic acid

KW - Vitamin A

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ER -

Retinoic acid: A key player in immunity

Abstract

Keywords

UN SDGs

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