Retinoic acid: A key player in immunity

Karina Pino-Lagos, Yanxia Guo, Randolph J. Noelle

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

For the past 100 years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment.
Original languageAmerican English
Pages (from-to)430-436
Number of pages7
JournalBioFactors
Volume36
Issue number6
DOIs
StatePublished - 1 Nov 2010
Externally publishedYes

Keywords

  • Inflammation
  • Retinoic acid
  • Vitamin A

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