Results of adjuvant chemoradiation after curative surgery for gastric cancer. A retrospective study: Análisis de supervivencia y toxicidad de pacientes tratados entre 1995 y 2003 en el Instituto Nacional del Cáncer, Chile

Bettina Müller*, Paulina Balbontín, Marcela Cárcamo, Cristian Trujillo, Sergio Becerra, Antonio Solá, Rodrigo Neveu, Roberto Fernández, Martín Buchholtz, Luis Villanueva, Berta Cerda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Survival rates after curative surgery for gastric cancer are disappointing. Therefore adjuvant therapeutic strategies are required. Aim: To analyze survival and side effects of treatment among gastric cancer patients treated with adjuvant chemoradiotherapy after curative resection of gastric adenocarcinoma. Material and methods: Retrospective review of medical records of 74 patients aged 20 to 74 years, treated with complete resection of gastric adenocarcinoma followed by adjuvant chemoradiation. Survival analysis was based on the records and information from the National Mortality Registry. Results: Five years survival fluctuated from 50% among patients in stage 1B to 25% among those is stage IV. Significant acute toxicity was observed in 23 patients (31%). No patients died due to acute toxicity. Eleven patients (16.4%) developed significant late toxicity, with two possible deaths related to treatment. Conclusions: Postoperative chemoradiotherapy is feasible in our experience. Continuos infusion of 5-fluoruracil is recommended to reduce toxicity.

Translated title of the contributionResults of adjuvant chemoradiation after curative surgery for gastric cancer. A retrospective study
Original languageSpanish
Pages (from-to)649-656
Number of pages8
JournalRevista Medica de Chile
Volume137
Issue number5
StatePublished - May 2009
Externally publishedYes

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