Regulatory Mechanisms of Muscle Mass: The Critical Role of Resistance Training in Children and Adolescent

F. Castelli, M. Valero-Breton, M. Hernandez, F. Guarda, J. Cornejo, C. Cabello-Verrugio, D. Cabrera*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Muscle mass and strength are subjected to several regulations. We found endocrine signals such as growth hormone, insulin-like growth factor 1, testosterone, thyroid hormones, and glucocorticoids among them. Neural inputs also influence muscle development, modulating mass and strength. Among the external stimuli that modulate these muscular features is physical training such as resistance and endurance training. Specifically, resistance training can mediate an increase in muscle mass by hypertrophy in adults, but the effects in children and adolescents are full of myths for most of the population. However, the evidence shows that the impact of resistance training on children and adolescents is clear and provides a wide range of benefits. However, qualified professionals must be available since exercise prescription and subsequent supervision must follow this population’s abilities, needs, and interests.

Original languageEnglish
Pages (from-to)21-34
Number of pages14
JournalAdvances in Experimental Medicine and Biology
StatePublished - 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.


  • Adolescent
  • Children
  • Cortisol
  • Glucocorticoids
  • Growth hormone
  • Hypertrophy
  • Muscle mass
  • Resistance training
  • Strength


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