A healthy dietary pattern and high quality nutrient intake reduce atherosclerotic cardiovascular disease risk. Red wine grape pomace (RWGP)—a rich natural source of dietary fiber and antioxidants—appears to be a potential functional food ingredient. The impact of a dietary supplementation with RWGP flour was evaluated in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice, a model of lethal ischemic heart disease. SR-B1 KO/ApoER61h/h mice were fed with atherogenic (high fat, cholesterol, and cholic acid, HFC) diet supplemented with: (a) 20% chow (HFC-Control), (b) 20% RWGP flour (HFC-RWGP), or (c) 10% chow/10% oat fiber (HFC-Fiber); and survival time was evaluated. In addition, SR-B1 KO/ApoER61h/h mice were fed for 7 or 14 days with HFC-Control or HFC-RWGP diets and plasma lipid levels, inflammation, oxidative damage, and antioxidant activity were measured. Atherosclerosis and myocardial damage were assessed by histology and magnetic resonance imaging, respectively. Supplementation with RWGP reduced premature death, changed TNF-α and IL-10 levels, and increased plasma antioxidant activity. Moreover, decreased atheromatous aortic and brachiocephalic plaque sizes and attenuated myocardial infarction and dysfunction were also observed. These results suggest that RWGP flour intake may be used as a non-pharmacological therapeutic approach, contributing to decreased progression of atherosclerosis, reduced coronary heart disease, and improved cardiovascular outcomes.
|State||Published - Sep 2019|
Bibliographical noteFunding Information:
Funding: This work was funded by research grants FONDECYT 1150399, FONDECYT 1180525, CONICYT-PIA-Anillo ACT1416 and well as the Millennium Nucleus for Cardiovascular Magnetic Resonance grant from the Ministry of Education and Ministry of Economy, Development and Tourism (Government of Chile).
This work was funded by research grants FONDECYT 1150399, FONDECYT 1180525, CONICYT-PIA-Anillo ACT1416 and well as the Millennium Nucleus for Cardiovascular Magnetic Resonance grant from the Ministry of Education and Ministry of Economy, Development and Tourism (Government of Chile).
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
- Fiber and antioxidants
- Grape pomace
- Magnetic resonance imaging
- Oxidative stress