Rat Urinary Chemiluminescence: Effect of Ethanol and/or Hexachlorobenzene Uptake

María Del Carmen Ríos De Molina, María Ana Suárez Lissi, Arnaldo Armesto, Carlos Lafourcade, Eduardo Lissi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Hexachlorobenzene (HCB) administration to rats induces porphyria cutanea tarda, characterized by high levels of urinary porphyrins (>40 μg/day) and accumulation of highly carboxylated porphyrins in liver (>15 μg/g of tissue). Ethanol administration, under the conditions employed, was not porphyrinogenic and was able to diminish some of the responses elicited by HCB. Furthermore, ethanol and/or HCB administration leads to organ disturbances that involve oxidative stress. We have measured the changes in urinary chemiluminescence (CL) levels, as part of a systematic evaluation of the metabolic alterations in rats chronically treated with ethanol and/or HCB. The results, that constitute the first set of urinary CL data obtained from an animal model system, indicate that the measurement of the spontaneous urinary CL can constitute a fast, simple and sensitive method to evaluate disturbances associated with oxidative stress.
Original languageAmerican English
Pages (from-to)63-68
Number of pages6
JournalLuminescence
Volume13
Issue number2
DOIs
StatePublished - 1 Jan 1998

Keywords

  • Ethanol
  • Hexachlorobenzene
  • Oxidative stress
  • Porphyria
  • Spontaneous urinary chemiluminescence

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