Radiofrequency echographic multi spectrometry (REMS) in the diagnosis and management of osteoporosis: state of the art

Nicholas R. Fuggle, Jean Yves Reginster, Nasser Al-Daghri, Olivier Bruyere, Nansa Burlet, Claudia Campusano, Cyrus Cooper, Adolfo Diez Perez, Philippe Halbout, Tullio Ghi, Jean Marc Kaufman, Andreas Kurt, Radmila Matijevic, Regis P. Radermecker, Sansin Tuzun, Nicola Veronese*, Rene Rizzoli, Nicholas C. Harvey, Maria Luisa Brandi, Maria Luisa Brandi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Radiofrequency Echographic Multi Spectrometry (REMS) is a radiation-free, portable technology, which can be used for the assessment and monitoring of osteoporosis at the lumbar spine and femoral neck and may facilitate wider access to axial BMD measurement compared with standard dual-energy x-ray absorptiometry (DXA). There is a growing literature demonstrating a strong correlation between DXA and REMS measures of BMD and further work supporting 5-year prediction of fracture using the REMS Fragility Score, which provides a measure of bone quality (in addition to the quantitative measure of BMD). The non-ionising radiation emitted by REMS allows it to be used in previously underserved populations including pregnant women and children and may facilitate more frequent measurement of BMD. The portability of the device means that it can be deployed to measure BMD for frail patients at the bedside (avoiding the complications in transfer and positioning which can occur with DXA), in primary care, the emergency department, low-resource settings and even at home. The current evidence base supports the technology as a useful tool in the management of osteoporosis as an alternative to DXA.

Original languageEnglish
Article number135
JournalAging clinical and experimental research
Issue number1
StatePublished - Dec 2024

Bibliographical note

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  • Diagnosis
  • Fracture
  • Osteoporosis
  • Radiofrequency echographic multi spectrometry (REMS)
  • Screening


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