Protective role of high density lipoproteins in sepsis: Basic issues and clinical implications

Susana Contreras-Duarte, Pablo Varas, Fernanda Awad, Dolores Busso, Attilio Rigotti

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

High density lipoproteins (HDL) are responsible of reverse cholesterol transport and play an important antiatherogenic role. In recent years, several studies suggest that HDL have additional functions, including a possible anti-inflammatory activity in infectious conditions. Furthermore, available evidence indicates that the presence of lipopolysaccharide (LPS) within the circulation during infectious states induced by gram-negative bacteria may be involved in the decrease in HDL cholesterol levels and changes in lipoprotein composition, which have been associated with a higher mortality due to sepsis in animal models and in humans. In this article, we review this subject and also discuss possible mechanisms that explain the positive impact achieved by native HDL, reconstituted HDL, or HDL apolipoprotein peptides on the inflammatory response and mortality in models of endotoxemia. In this regard, it has been proposed that one of the mechanisms by which HDL protect against sepsis may be mediated by its binding ability and/or neutralizing capacity on LPS, avoiding an excessive response of the immune system. Thus, increasing blood levels of HDL and/or parenteral HDL administration may represent a new anti-inflammatory tool for managing septic states in humans.
Original languageAmerican English
Pages (from-to)34-43
Number of pages10
JournalRevista Chilena de Infectologia
Volume31
Issue number1
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

Keywords

  • (Tnf-α)
  • Apo A-I mimetic peptide (L-4f)
  • Apolipoprotein A-I (APO A-I)
  • High density lipoproteins (HDL)
  • Interleukin-6 (Il-6)
  • Lipopolysaccharide (LPS)
  • Reconstituted HDL (RHDL)
  • Tumor necrosis factor α

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