TY - JOUR
T1 - Prognostic value of immunoexpression of ccr4, ccr5, ccr7 and cxcr4 in squamous cell carcinoma of tongue and floor of the mouth
AU - Domingueti, Catherine Bueno
AU - Janini, João Baptista Macuco
AU - Paranaíba, Lívia Máris Ribeiro
AU - Lozano-Burgos, Carlo
AU - Olivero, Pablo
AU - González-Arriagada, Wilfredo Alejandro
N1 - Publisher Copyright:
© Medicina Oral S. L.
PY - 2019/5
Y1 - 2019/5
N2 - Background: Diverse studies have evidenced that chemokines can play a critical role in pathogenesis of oral squamous cell carcinoma (SCC). The main chemokines involved in oral carcinogenesis, tumor invasion and metastasis are CCR4, CCR5, CCR7 and CXCR4, and our aim was to evaluate the prognostic value of the immunoexpression of these chemokines in SCC of tongue and floor of the mouth. Material and Methods: A retrospective descriptive study of the immunohistochemical expression of CCR4, CCR5, CCR7 and CXCR4 in paraffin-embedded samples of 124 patients with SCC of the tongue and floor of the mouth was performed, considering 98 cases from Brazil and 26 cases from Chile. Associations between variables were analyzed using chi-square test. Survival curves were performed using the Kaplan-Meier method and compared with long-rank test. For multivariate survival analysis, the Cox hazard model was established. The level of significance established was p≤0.05. Results: The statistical analysis showed that samples with well or moderate WHO model differentiation (p=0.001) and a high expression of CCR5 (p=0.05) were significantly associated with a higher disease specific survival, which were also observed in Cox´s multivariate analysis (p=0.01). A higher expression of CCR7 (p=0.01) interfered significantly in disease-free survival in univariate analysis and in Cox´s multivariate analysis (p=0.05). Conclusions: These results support additional evidence, showing that chemokine receptors CCR5 and CCR7 are helpful as biomarkers of poor prognosis in patients with SCC of the tongue and floor of the mouth.
AB - Background: Diverse studies have evidenced that chemokines can play a critical role in pathogenesis of oral squamous cell carcinoma (SCC). The main chemokines involved in oral carcinogenesis, tumor invasion and metastasis are CCR4, CCR5, CCR7 and CXCR4, and our aim was to evaluate the prognostic value of the immunoexpression of these chemokines in SCC of tongue and floor of the mouth. Material and Methods: A retrospective descriptive study of the immunohistochemical expression of CCR4, CCR5, CCR7 and CXCR4 in paraffin-embedded samples of 124 patients with SCC of the tongue and floor of the mouth was performed, considering 98 cases from Brazil and 26 cases from Chile. Associations between variables were analyzed using chi-square test. Survival curves were performed using the Kaplan-Meier method and compared with long-rank test. For multivariate survival analysis, the Cox hazard model was established. The level of significance established was p≤0.05. Results: The statistical analysis showed that samples with well or moderate WHO model differentiation (p=0.001) and a high expression of CCR5 (p=0.05) were significantly associated with a higher disease specific survival, which were also observed in Cox´s multivariate analysis (p=0.01). A higher expression of CCR7 (p=0.01) interfered significantly in disease-free survival in univariate analysis and in Cox´s multivariate analysis (p=0.05). Conclusions: These results support additional evidence, showing that chemokine receptors CCR5 and CCR7 are helpful as biomarkers of poor prognosis in patients with SCC of the tongue and floor of the mouth.
KW - Chemokine receptor
KW - Oral squamous cell carcinoma
KW - Prognosis
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85065509312&partnerID=8YFLogxK
U2 - 10.4317/medoral.22904
DO - 10.4317/medoral.22904
M3 - Article
C2 - 31011147
AN - SCOPUS:85065509312
SN - 1698-4447
VL - 24
SP - e354-e363
JO - Medicina Oral Patologia Oral y Cirugia Bucal
JF - Medicina Oral Patologia Oral y Cirugia Bucal
IS - 3
ER -