Prognostic value of immunoexpression of ccr4, ccr5, ccr7 and cxcr4 in squamous cell carcinoma of tongue and floor of the mouth

Catherine Bueno Domingueti, João Baptista Macuco Janini, Lívia Máris Ribeiro Paranaíba, Carlo Lozano-Burgos, Pablo Olivero, Wilfredo Alejandro González-Arriagada

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Diverse studies have evidenced that chemokines can play a critical role in pathogenesis of oral squamous cell carcinoma (SCC). The main chemokines involved in oral carcinogenesis, tumor invasion and metastasis are CCR4, CCR5, CCR7 and CXCR4, and our aim was to evaluate the prognostic value of the immunoexpression of these chemokines in SCC of tongue and floor of the mouth. Material and Methods: A retrospective descriptive study of the immunohistochemical expression of CCR4, CCR5, CCR7 and CXCR4 in paraffin-embedded samples of 124 patients with SCC of the tongue and floor of the mouth was performed, considering 98 cases from Brazil and 26 cases from Chile. Associations between variables were analyzed using chi-square test. Survival curves were performed using the Kaplan-Meier method and compared with long-rank test. For multivariate survival analysis, the Cox hazard model was established. The level of significance established was p≤0.05. Results: The statistical analysis showed that samples with well or moderate WHO model differentiation (p=0.001) and a high expression of CCR5 (p=0.05) were significantly associated with a higher disease specific survival, which were also observed in Cox´s multivariate analysis (p=0.01). A higher expression of CCR7 (p=0.01) interfered significantly in disease-free survival in univariate analysis and in Cox´s multivariate analysis (p=0.05). Conclusions: These results support additional evidence, showing that chemokine receptors CCR5 and CCR7 are helpful as biomarkers of poor prognosis in patients with SCC of the tongue and floor of the mouth.

Original languageEnglish
Pages (from-to)e354-e363
JournalMedicina Oral Patologia Oral y Cirugia Bucal
Volume24
Issue number3
DOIs
StatePublished - May 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Medicina Oral S. L.

Keywords

  • Chemokine receptor
  • Oral squamous cell carcinoma
  • Prognosis
  • Survival

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