Primary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation

Paulina Núñez F.*, Rodrigo Quera P., Fernando Gomollón

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The association between inflammatory bowel disease (IBD)and primary sclerosing cholangitis should be considered a distinct clinical entity. This association involves genetic abnormalities, epidemiological factors (more common in men, with no a geographical pattern)and, commonly, subclinical inflammation, predominance of the right colon (endoscopic and histological), backwash ileitis and rectal sparing. Furthermore, there is an increased risk of colorectal cancer and cholangiocarcinoma. The aim of this review is to show how IBD influences the progression of this entity, transplantation requirements and recurrence. We also discuss the current evidence on the use of biological therapy in this group of patients.

Translated title of the contributionPrimary sclerosing cholangitis and inflammatory bowel disease: Intestine-liver interrelation
Original languageSpanish
Pages (from-to)316-325
Number of pages10
JournalGastroenterologia y Hepatologia
Volume42
Issue number5
DOIs
StatePublished - May 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 Elsevier España, S.L.U.

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