Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus

Carlos A. Lafourcade

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or longlasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression. Among these, the proteins PKA and RIM1α appear to be crucial, although other possibilities are emerging.

Original languageEnglish
Pages (from-to)2009-2012
Number of pages4
JournalJournal of Neurophysiology
Issue number4
StatePublished - Oct 2009
Externally publishedYes

Bibliographical note

Copyright: © 2009 The American Physiological Society.


Dive into the research topics of 'Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus'. Together they form a unique fingerprint.

Cite this