TY - JOUR
T1 - Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus
AU - Lafourcade, Carlos A.
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or longlasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression. Among these, the proteins PKA and RIM1α appear to be crucial, although other possibilities are emerging. Copyright
AB - Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or longlasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression. Among these, the proteins PKA and RIM1α appear to be crucial, although other possibilities are emerging. Copyright
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U2 - 10.1152/jn.00441.2009
DO - 10.1152/jn.00441.2009
M3 - Scientific review
VL - 102
SP - 2009
EP - 2012
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
SN - 0022-3077
IS - 4
ER -