Premature rupture of membranes at preterm. Meta-analysis of the effect of steroids on the prevention of respiratory distress syndrome

E. Oyarzún, R. Gómez, R. Romero, M. Bracken

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The use of steroids in premature rupture of the membranes is controversial. We used meta-analysis of published results to evaluate the effect of steroid treatment to prevent fetal respiratory distress syndrome associated to premature rupture of the membranes and found that a 30% reduction in the rate of this complication was observed in patients receiving steroids. The 95% confidence interval for relative risk was 0.610 to 0.815. However, infectious complication of the mother increased (mean relative risk 1.68, 95% Cl 1.16-2.44) but not those of the neonate. These results support the use of steroids in order to prevent fetal respiratory distress syndrome in pregnant women with premature rupture of membranes.
Original languageAmerican English
Pages (from-to)388-395
Number of pages8
JournalRevista médica de Chile
Volume119
Issue number4
StatePublished - 1 Jan 1991
Externally publishedYes

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