A full-scale reinforced concrete (R/C) building specimen, furnished with a variety of nonstructural components and systems, was built and tested on the UCSD-NEES outdoor shake table. The building specimen was subjected to a sequence of dynamic tests including scaled and unscaled historical earthquake ground motions. In order to simulate and predict the nonlinear dynamic response of the building specimen, a detailed three-dimensional nonlinear FE model of the structure was developed using the FE analysis software DIANA. By comparing the pre-test simulated results with the experimental results, the effects of the nonstructural components on the dynamic response of the building can be inferred. This paper describes the building test specimen and the nonlinear FE modeling and response simulation. Key numerical results are compared with their experimental counterparts and potential sources of discrepancies are discussed.