Abstract
Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPARβ/δ has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPARβ/δ not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-κB activity. In this review, we discuss how the regulation of PPARβ/δ provides an innovative strategy for an optimisation of MSC-based therapy.
Original language | English |
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Pages (from-to) | 55-58 |
Number of pages | 4 |
Journal | Biochimie |
Volume | 136 |
DOIs | |
State | Published - 1 May 2017 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)