PPARβ/δ: A master regulator of mesenchymal stem cell functions

Farida Djouad, Natacha Ipseiz, Patricia Luz-Crawford, Carina Scholtysek, Gerhard Krönke, Christian Jorgensen

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations

Abstract

. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPARβ/δ has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPARβ/δ not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-κB activity. In this review, we discuss how the regulation of PPARβ/δ provides an innovative strategy for an optimisation of MSC-based therapy.
Original languageAmerican English
Pages (from-to)55-58
Number of pages4
JournalBiochimie
Volume136
DOIs
StatePublished - 1 May 2017

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