Population attributable fraction of modifiable risk factors for dementia in Chile

Rodrigo C. Vergara, Pedro Zitko, Andrea Slachevsky, Consuelo San Martin, Carolina Delgado*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Introduction: Projected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia-prevention strategies. Methods: We analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia-free subjects ≥45-years-old, using the 2016-2017 Chilean National Health Survey. Results: The overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to -56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women. Discussion: The PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention. HIGHLIGHTS: The proportion of dementia associated to modifiable risk factors in Chile is 45.8%. The main modifiable risk factors are high blood pressure, obesity, and hearing loss. Women had a greater prevalence of physical inactivity and depression than men. Chile had a greater prevalence of metabolic risk factors than other world regions.

Original languageEnglish
Article numbere12273
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Issue number1
StatePublished - 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.


  • cardiovascular
  • dementia
  • depression
  • hypertension
  • Latin America and the Caribbean
  • midlife
  • modifiable risk factors
  • obesity
  • physical inactivity
  • population attributable fraction
  • prevention


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