Population attributable fraction of modifiable risk factors for dementia in Chile

Rodrigo C. Vergara; Pedro Zitko; Andrea Slachevsky; Consuelo San Martin; Carolina Delgado

doi:10.1002/dad2.12273

Population attributable fraction of modifiable risk factors for dementia in Chile

Rodrigo C. Vergara, Pedro Zitko, Andrea Slachevsky, Consuelo San Martin, Carolina Delgado^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Introduction: Projected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia-prevention strategies. Methods: We analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia-free subjects ≥45-years-old, using the 2016-2017 Chilean National Health Survey. Results: The overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to -56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women. Discussion: The PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention. HIGHLIGHTS: The proportion of dementia associated to modifiable risk factors in Chile is 45.8%. The main modifiable risk factors are high blood pressure, obesity, and hearing loss. Women had a greater prevalence of physical inactivity and depression than men. Chile had a greater prevalence of metabolic risk factors than other world regions.

Original language	English
Article number	e12273
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	14
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12273
State	Published - 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.

Keywords

cardiovascular
dementia
depression
hypertension
Latin America and the Caribbean
midlife
modifiable risk factors
obesity
physical inactivity
population attributable fraction
prevention

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/dad2.12273

Cite this

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title = "Population attributable fraction of modifiable risk factors for dementia in Chile",

abstract = "Introduction: Projected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia-prevention strategies. Methods: We analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia-free subjects ≥45-years-old, using the 2016-2017 Chilean National Health Survey. Results: The overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to -56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women. Discussion: The PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention. HIGHLIGHTS: The proportion of dementia associated to modifiable risk factors in Chile is 45.8%. The main modifiable risk factors are high blood pressure, obesity, and hearing loss. Women had a greater prevalence of physical inactivity and depression than men. Chile had a greater prevalence of metabolic risk factors than other world regions.",

keywords = "cardiovascular, dementia, depression, hypertension, Latin America and the Caribbean, midlife, modifiable risk factors, obesity, physical inactivity, population attributable fraction, prevention",

author = "Vergara, {Rodrigo C.} and Pedro Zitko and Andrea Slachevsky and {San Martin}, Consuelo and Carolina Delgado",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",

year = "2022",

doi = "10.1002/dad2.12273",

language = "English",

volume = "14",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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AU - Zitko, Pedro

AU - Slachevsky, Andrea

AU - San Martin, Consuelo

AU - Delgado, Carolina

PY - 2022

Y1 - 2022

N2 - Introduction: Projected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia-prevention strategies. Methods: We analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia-free subjects ≥45-years-old, using the 2016-2017 Chilean National Health Survey. Results: The overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to -56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women. Discussion: The PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention. HIGHLIGHTS: The proportion of dementia associated to modifiable risk factors in Chile is 45.8%. The main modifiable risk factors are high blood pressure, obesity, and hearing loss. Women had a greater prevalence of physical inactivity and depression than men. Chile had a greater prevalence of metabolic risk factors than other world regions.

AB - Introduction: Projected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia-prevention strategies. Methods: We analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia-free subjects ≥45-years-old, using the 2016-2017 Chilean National Health Survey. Results: The overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to -56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women. Discussion: The PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention. HIGHLIGHTS: The proportion of dementia associated to modifiable risk factors in Chile is 45.8%. The main modifiable risk factors are high blood pressure, obesity, and hearing loss. Women had a greater prevalence of physical inactivity and depression than men. Chile had a greater prevalence of metabolic risk factors than other world regions.

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ER -

Population attributable fraction of modifiable risk factors for dementia in Chile

Abstract

Bibliographical note

Keywords

UN SDGs

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