Polymeric nanoparticle systems: Structure, elaboration methods, characteristics, properties, biofunctionalization and self-assembly layer by layer technologies

Madelein C. Urrejola, Liliam V. Soto, Consuelo C. Zumarán, Juan Pablo Peñaloza, Beatriz Álvarez, Ignacio Fuentevilla, Ziyad S. Haidar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

SUMMARY: Polymeric materials have been extensively investigated for biomedical applications including micro-and nanoparticles. Modern advances have broadened horizons for application with peptides and nucleic acids. Therefore, interests increased in the formulation of materials, devices and vehicles for transporting therapeutic agents in functionalized nanostructures. Recent nano-systems are inspired by natural phenomena that stimulate the integration of molecular signals and the mimicking of natural cellular processes, at tissue and organ levels. Technologically, the ability to obtain spherical nanostructures, which combine different properties, that no other single material possesses on its own, makes nanocapsules particularly attractive. Potential advantages over polymer nanoparticulate systems are highlighted throughout each part of this review article. Here, we address the most relevant aspects of structure, composition and methods of formulation of nanoparticulate systems. In addition, we outline some of the more recent works focusing on nanosized preparations, based on agent-directed polymers, found in specialized research articles that have emerged in the recent years.

Translated title of the contributionPolymeric nanoparticle systems: Structure, elaboration methods, characteristics, properties, biofunctionalization and self-assembly layer by layer technologies
Original languageSpanish
Pages (from-to)1463-1471
Number of pages9
JournalInternational Journal of Morphology
Volume36
Issue number4
DOIs
StatePublished - Dec 2018

Bibliographical note

Funding Information:
Este trabajo fue apoyado por las subvenciones de funcionamiento otorgadas al BioMAT'X (La-boratorio de Biomateriales, Farmacéuticos y Bioingeniería de Tejidos Cráneo Máxilo-Facial), miembro del CIIB (Centro de Investigación e Innovación Biomédica), a través de la Facultad de Odontología y Fondo de Ayuda a la Investigación (FAI No. INV-IN-2015-101 2015-2019), Dirección de Investigación, Universidad de los Andes, Santiago de Chile y CONICYT-FONDEF (Grant ID # 16I10366).

Publisher Copyright:
© 2019, Universidad de la Frontera. All rights reserved.

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