Polymer nanoparticle systems: From biodetection and glucose monitoring in diabetes to bioimaging, nano-oncology, gene therapy, tissue engineering / regeneration to nano-dentistry

Madelein C. Urrejola, Liliam V. Soto, Consuelo C. Zumarán, Juan Pablo Peñaloza, Beatriz Álvarez, Ignacio Fuentevilla, Ziyad S. Haidar

Research output: Contribution to journalArticlepeer-review

Abstract

Nanotechnology is the science that involves the synthesis of materials in scale between 1-100 nm (nanomaterials) and is applicable in different areas such as environment, electronics, food, energy, among others. The fields that will be relevant within this review and explained in detail are nanomedicine and nano-dentistry. Currently, in these areas, the three main topics under development are specifically in the sub-area of nanobiotechnology and correspond to: sensorization (biosensors / biosensing), diagnostics (biomarkers / bioimaging) and transport of genes, proteins or drugs (exchange systems) controlled in systemic versus localized targets). Advances have also been presented in bioapplications such as membrane modeling, cell marking, delivery of agents to specific targets, strategies for disease prevention, tissue engineering, organ regeneration, immunoassay strategies and nano-oncology. This review article aims to address some of the most relevant contributions, some of the recent work, on nanoparticle systems, mainly those aimed at therapies in areas such as diabetes, nano-oncology, drug and gene therapy, through the layer-by-layer and self-assembled technique, also widely used in tissue engineering and tissue regeneration, together with a brief summary of the advances that exist in the field of nano-dentistry.

Translated title of the contributionPolymer nanoparticle systems: From biodetection and glucose monitoring in diabetes to bioimaging, nano-oncology, gene therapy, tissue engineering / regeneration to nano-dentistry
Original languageSpanish
Pages (from-to)1490-1499
Number of pages10
JournalInternational Journal of Morphology
Volume36
Issue number4
DOIs
StatePublished - Dec 2018

Bibliographical note

Funding Information:
Este trabajo fue apoyado por las subvenciones de funcionamiento otorgadas al BioMAT'X (Laboratorio de Biomateriales, Farmacéuticos y Bioingeniería de Tejidos Cráneo Máxilo-Facial), miembro del CIIB (Centro de Investigación e Innovación Biomédica), a través de la Facultad de Odontología y Fondo de Ayuda a la Investigación (FAI No. INV-IN-2015-101 2015-2019), Dirección de Investigación, Universidad de los Andes, Santiago de Chile y CONICYT-FONDEF (Grant ID # 16I10366).

Publisher Copyright:
© 2019, Universidad de la Frontera. All rights reserved.

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