TY - JOUR
T1 - Plasmacytoma and plasma cell myeloma affecting the jaws
T2 - A multi-institutional collaborative study
AU - Souza, Lucas Lacerda de
AU - Cáceres, Cinthia Verónica Bardález López de
AU - Vargas, Pablo Agustin
AU - Lopes, Márcio Ajudarte
AU - Santos-Silva, Alan Roger
AU - Silva, Wagner Gomes da
AU - Prado-Ribeiro, Ana Carolina
AU - Brandão, Thais Bianca
AU - Pereira, Juliana
AU - Mesquita, Ricardo Alves
AU - Pontes, Flávia Sirotheau Correa
AU - González-Arriagada, Wilfredo Alejandro
AU - Pedraza, Ricardo Martinez
AU - Andrade, Bruno Augusto Benevenuto de
AU - Romañach, Mario José
AU - Soares, Ciro Dantas
AU - Carvalho, Maria Goretti Freire de
AU - Pires, Fabio Ramôa
AU - Carlos, Roman
AU - Fonseca, Felipe Paiva
AU - Pontes, Hélder Antônio Rebelo
AU - de Almeida, Oslei Paes
N1 - Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2021/7
Y1 - 2021/7
N2 - BACKGROUND: Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. They can manifest as a single lesion (plasmacytoma) or as multiple lesions (multiple myeloma).METHODS: Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed and follow-up status were retrieved from the pathology reports.RESULTS: Fifty-two cases were retrieved (mean age: 59.4 years) without sex predilection. The mandible was the most affected site (67.3%), usually associated with pain and/or paresthesia (53.8%). Lesions in other bones besides the jaws were reported for 24 patients (46.2%). Radiographically, tumours usually presented as poorly defined osteolytic lesions with unilocular or multilocular images, while microscopy revealed diffuse proliferation of neoplastic plasma cells with nuclear displacement and abundant eosinophilic cytoplasm. Two cases were classified as anaplastic, and amyloid deposits were found in two other cases. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, and monoclonality for kappa light chain predominated. The overall survival rate after 5 years of follow-up was 26.6%.CONCLUSION: Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations.
AB - BACKGROUND: Plasma cell neoplasms are characterized by the proliferation of a single clone of plasma cells with production of a monoclonal immunoglobulin. They can manifest as a single lesion (plasmacytoma) or as multiple lesions (multiple myeloma).METHODS: Paraffin-embedded tissue blocks of patients microscopically diagnosed with plasma cell neoplasms in the jaws were retrieved from five pathology files. Data including clinical, radiographic, microscopic and immunohistochemical findings, treatment employed and follow-up status were retrieved from the pathology reports.RESULTS: Fifty-two cases were retrieved (mean age: 59.4 years) without sex predilection. The mandible was the most affected site (67.3%), usually associated with pain and/or paresthesia (53.8%). Lesions in other bones besides the jaws were reported for 24 patients (46.2%). Radiographically, tumours usually presented as poorly defined osteolytic lesions with unilocular or multilocular images, while microscopy revealed diffuse proliferation of neoplastic plasma cells with nuclear displacement and abundant eosinophilic cytoplasm. Two cases were classified as anaplastic, and amyloid deposits were found in two other cases. Immunohistochemistry was positive for plasma cell markers and negative for CD20 and CD3, and monoclonality for kappa light chain predominated. The overall survival rate after 5 years of follow-up was 26.6%.CONCLUSION: Plasma cell neoplasms are aggressive tumours with a poor prognosis and involvement of the jaws may be the first complaint of the patient. Thus, oral pathologists, head and neck surgeons and dentists should be aware of their clinical, radiographic and microscopic manifestations.
KW - Humans
KW - Immunohistochemistry
KW - Jaw/diagnostic imaging
KW - Middle Aged
KW - Multiple Myeloma/diagnostic imaging
KW - Neoplasms, Plasma Cell/diagnostic imaging
KW - Plasmacytoma/diagnostic imaging
UR - http://www.scopus.com/inward/record.url?scp=85108264867&partnerID=8YFLogxK
U2 - 10.1111/jop.13213
DO - 10.1111/jop.13213
M3 - Article
C2 - 34089204
SN - 0904-2512
VL - 50
SP - 613
EP - 621
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
IS - 6
ER -