Plasma cross-gestational sphingolipidomic analyses reveal potential first trimester biomarkers of preeclampsia

Agriculture & Biology

• pre-eclampsia 100%
• sphingomyelins 77%
• biomarkers 58%
• ceramides 40%
• sphingolipids 35%
• pregnancy 29%
• sphingosine 27%
• phosphates 14%
• tandem mass spectrometry 7%
• sampling 7%
• high performance liquid chromatography 6%
• proteinuria 5%
• premature birth 5%
• metabolic syndrome 5%
• retrospective studies 5%
• reversed-phase liquid chromatography 5%
• electrospray ionization mass spectrometry 4%
• hypertension 4%
• morbidity 4%
• edema 4%
• signs and symptoms (animals and humans) 3%
• experimental design 3%
• prediction 2%
• methodology 1%

Medicine & Life Sciences

• Sphingomyelins 79%
• First Pregnancy Trimester 67%
• Pre-Eclampsia 64%
• Biomarkers 42%
• Ceramides 38%
• Sphingolipids 34%
• sphingosine 1-phosphate 26%
• Pregnancy 24%
• Mothers 15%
• Second Pregnancy Trimester 8%
• High Pressure Liquid Chromatography 6%
• Surrogate Mothers 5%
• Fetal Mortality 5%
• Reverse-Phase Chromatography 5%
• Tandem Mass Spectrometry 4%
• Third Pregnancy Trimester 4%
• Premature Birth 4%
• Proteinuria 3%
• Metabolic Syndrome 3%
• Edema 3%
• Up-Regulation 2%
• Retrospective Studies 2%
• Hypertension 2%
• Morbidity 2%

Chemical Compounds

• Sphingomyelin 74%
• Biological Marker 58%
• Ceramide 48%
• Sphingolipid 46%
• Sphingomyelin 16:0 43%
• Plasma 40%
• Sphingosine 1-Phosphate 15%
• Angiogenic 14%
• Plasma Level 6%
• Disorder 4%
• Metabolic 4%
• Molecule 1%