PLA/PGA and its co-Polymers in Alveolar Bone Regeneration. A Systematic Review

Marcelo Parra, María Paz Moya, Carolina Rebolledo, Ziyad S Haidar, Juan Pablo Alister, Sergio Olate

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ABSTRACT: The aim of this research was to perform a systematic review to identify the most frequent uses of PLA/ PGA in alveolar bone regeneration and their results. A study was designed to answer the question: What are the most frequent uses of PLA/PLGA and their copolymers in alveolar bone regeneration?. A systematic search was done on MEDLINE, EMBASE and LILACS from April 1993 to December 2017. The search string used on MEDLINE was: (((polylactic acid) OR PLA) OR PLA-based copolymers) OR PLA blends) OR PLA scaffolds)) AND ((("Bone Regeneration"[Mesh]) OR bone regeneration) OR guided bone regeneration). The search was complemented by a manual review of the references from the articles included. Most of the studies selected were weak and, regarding the most frequent uses of PLA/PGA, 13 studies used it as a resorbable membrane, two as an absorbable mesh, one as an absorbable screw and three as filling material. Based on our results, the authors consider that PLA/PGA requires a delicate relation between the mechanical resistance and the degradation process. PLA/PGA does not interrupt bone regeneration; however, the influence in cellular events related to bone regeneration and later osseointegration have not been identified.
Translated title of the contributionPLA/PGA y sus Copolímeros en Regeneración Ósea Alveolar. Una Revisión Sistemática
Original languageEnglish
Pages (from-to)258-265
JournalInternational journal of odontostomatology
Issue number3
StatePublished - 9 Aug 2019


  • poly lactic acid poly ethylene glycol
  • bone substitute
  • bone grafting


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