Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects

F. Figueroa*, F. Carrión, G. González, S. Rivero, E. Arteaga, I. Mamani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Prolactin markedly influences cellular and humoral immunity in animals, but there is little information on its role in men. The aim of this work was to study the immune effects of pharmacological modification of prolactin levels in 5 healthy individuals. Peripheral blood mononuclear cell proliferative response to mitogens and antigens, interleukin-2 (IL-2) production, soluble and membrane IL-2 receptor expression in peripheral blood mononuclear cells and serum soluble IL-2 receptors were successively measured during normoprolactinemia, during bromocriptine induced hypoprolactinemia and during metoclopramide induced hyperprolactinemia. There was a significant increase in cellular proliferation during hypoprolactinemia when compared with hyperprolactinemia. No concomitant changes in soluble or membrane receptor expression or IL-2 production were observed. It is concluded that lymphocyte proliferative response to mitogens is dependent on prolactin levels in man and that this effects is not mediated by IL-2 or its receptors. These results may be potentially relevant in clinic since changes in serum prolactin have been described in different autoimmune diseases.

Translated title of the contributionPharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects
Original languageSpanish
Pages (from-to)975-981
Number of pages7
JournalRevista Medica de Chile
Volume121
Issue number9
StatePublished - Sep 1993
Externally publishedYes

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