PEPTIDES | Endocannabinoids, Opioids and the Regulation of Hippocampal Inhibition

C. Lafourcade, M. A. Karson, B. E. Alger

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Endogenous regulators of inhibitory synaptic transmission strongly influence principal cell excitability. Deficits in such regulation could contribute to the development of epileptiform discharges in single cells as well as disturbed neuronal circuit activity. In this article we review the endogenous opioid and cannabinoid systems in the hippocampus. We compare their roles in regulating inhibitory synaptic transmission, and discuss recent evidence that suggests that they may overlap and perhaps interact.

Original languageEnglish
Title of host publicationEncyclopedia of Basic Epilepsy Research
Number of pages10
ISBN (Electronic)9780123739612
StatePublished - 1 Jan 2009
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2009 Elsevier Ltd. All rights reserved.


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  • Cholecystokinin
  • DHPG
  • DSI
  • GABA
  • GABA
  • Inhibitory long-term depression
  • Interneuron
  • Metabotropic glutmate
  • Mu opioid receptor
  • Neuroprotection
  • Parvalbumin
  • Seizure


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