Passage of albumin from the middle ear to the inner ear in otitis media in the chinchilla

Burt Goldberg, Marcus V. Goycoolea, Patrick M. Schleivert, Donald Shea, Patricia Schachern, Michael M. Paparella, Anna Maria Carpenter

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A study of the permeability of the middle ear-inner ear interface for macromolecules was carried out in chinchillas with open and obstructed eustachian tubes utilizing tritiated human serum albumin and immunoelectrophoresis. Tritiated albumin was placed in the round window niche area of normal animals and animals in which the eustachian tubes had been obstructed for 24 hours or 14 days. The tritiated albumin was allowed to remain in the middle ear cavity for 24 hours. Samples of middle ear effusion, perilymph, blood and cerebrospinal fluid were collected and measured for radioactivity. Radioactivity was demonstrated in the perilymph. Samples of middle ear effusions and perillymph were also studied by immunoelectrophoresis with goat antihuman albumin. Albumin placed in the round window niche of an experimental animal could be recovered unchanged in the perilymph. The results suggest a pathophysiologic explanation for the association of otitis media and sensorineural hearing loss or endolymphatic hydrops.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number3
StatePublished - Aug 1981
Externally publishedYes

Bibliographical note

Publisher Copyright: © 1981


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