TY - JOUR
T1 - Papel protector de las lipoproteínas de alta densidad en sepsis
T2 - Aspectos básicos e implicancias clínicas
AU - Contreras-Duarte, Susana
AU - Varas, Pablo
AU - Awad, Fernanda
AU - Busso, Dolores
AU - Rigotti, Attilio
PY - 2014/2
Y1 - 2014/2
N2 - High density lipoproteins (HDL) are responsible of reverse cholesterol transport and play an important antiatherogenic role. In recent years, several studies suggest that HDL have additional functions, including a possible anti-inflammatory activity in infectious conditions. Furthermore, available evidence indicates that the presence of lipopolysaccharide (LPS) within the circulation during infectious states induced by gram-negative bacteria may be involved in the decrease in HDL cholesterol levels and changes in lipoprotein composition, which have been associated with a higher mortality due to sepsis in animal models and in humans. In this article, we review this subject and also discuss possible mechanisms that explain the positive impact achieved by native HDL, reconstituted HDL, or HDL apolipoprotein peptides on the inflammatory response and mortality in models of endotoxemia. In this regard, it has been proposed that one of the mechanisms by which HDL protect against sepsis may be mediated by its binding ability and/or neutralizing capacity on LPS, avoiding an excessive response of the immune system. Thus, increasing blood levels of HDL and/or parenteral HDL administration may represent a new anti-inflammatory tool for managing septic states in humans.
AB - High density lipoproteins (HDL) are responsible of reverse cholesterol transport and play an important antiatherogenic role. In recent years, several studies suggest that HDL have additional functions, including a possible anti-inflammatory activity in infectious conditions. Furthermore, available evidence indicates that the presence of lipopolysaccharide (LPS) within the circulation during infectious states induced by gram-negative bacteria may be involved in the decrease in HDL cholesterol levels and changes in lipoprotein composition, which have been associated with a higher mortality due to sepsis in animal models and in humans. In this article, we review this subject and also discuss possible mechanisms that explain the positive impact achieved by native HDL, reconstituted HDL, or HDL apolipoprotein peptides on the inflammatory response and mortality in models of endotoxemia. In this regard, it has been proposed that one of the mechanisms by which HDL protect against sepsis may be mediated by its binding ability and/or neutralizing capacity on LPS, avoiding an excessive response of the immune system. Thus, increasing blood levels of HDL and/or parenteral HDL administration may represent a new anti-inflammatory tool for managing septic states in humans.
KW - (Tnf-α)
KW - Apo A-I mimetic peptide (L-4f)
KW - Apolipoprotein A-I (APO A-I)
KW - High density lipoproteins (HDL)
KW - Interleukin-6 (Il-6)
KW - Lipopolysaccharide (LPS)
KW - Reconstituted HDL (RHDL)
KW - Tumor necrosis factor α
UR - http://www.scopus.com/inward/record.url?scp=84898472546&partnerID=8YFLogxK
U2 - 10.4067/S0716-10182014000100005
DO - 10.4067/S0716-10182014000100005
M3 - Article
C2 - 24740772
AN - SCOPUS:84898472546
SN - 0716-1018
VL - 31
SP - 34
EP - 43
JO - Revista Chilena de Infectologia
JF - Revista Chilena de Infectologia
IS - 1
ER -