Oral squamous cell carcinomas and oral potentially malignant disorders: a Latin American study

Gerardo Gilligan; René Panico; Jerónimo Lazos; Rosana Morelatto; Paola Belardinelli; Ines Criscuolo; Nicolas Bolesina; Ignacio Molina Ávila; Juan Martin Pimentel Solá; Emilce Rivarola; Maria Jimena Morgante; Maria Eugenia Ingrassia Tonelli; Javier Gimenez; Pablo Doratti; Laura Cecilia Werner; Ana Carolina Prado-Ribeiro; Thais Bianca Brandão; Aljomar Jose Vechiato-Filho; Maria Claudia Cuzzullin; Cristina Saldivia-Siracusa; Marcio Ajudarte Lopes; Michelle Agostini; Mario José Romañach; Aline Corrêa Abrahão; Thamyres Campos Fonsêca; Estela Kaminagakura; Ana Lia Anbinder; Kamilla Santos Alves; Maria Leticia de Almeida Lança; Sonia Sacsaquispe-Contreras; Karem Rodriguez Ibazetta; Roberto Gerber-Mora; Saray Aranda Romo; Francisco Javier Tejeda Nava; Karina Cordero-Torres; Ricardo Moreno Silva; Wilfredo Gonzalez-Arriagada; Raiza Toro; Felipe Martins Silveira; Natalia Gonzalez; Pablo Agustin Vargas; Alan Roger Santos-Silva; Ronell Bologna-Molina; Mariana Villarroel-Dorrego; Benjamin Martinez; Eduardo Piemonte

doi:10.1111/odi.14778

Oral squamous cell carcinomas and oral potentially malignant disorders: a Latin American study

Gerardo Gilligan^*, René Panico, Jerónimo Lazos, Rosana Morelatto, Paola Belardinelli, Ines Criscuolo, Nicolas Bolesina, Ignacio Molina Ávila, Juan Martin Pimentel Solá, Emilce Rivarola, Maria Jimena Morgante, Maria Eugenia Ingrassia Tonelli, Javier Gimenez, Pablo Doratti, Laura Cecilia Werner, Ana Carolina Prado-Ribeiro, Thais Bianca Brandão, Aljomar Jose Vechiato-Filho, Maria Claudia Cuzzullin, Cristina Saldivia-SiracusaMarcio Ajudarte Lopes, Michelle Agostini, Mario José Romañach, Aline Corrêa Abrahão, Thamyres Campos Fonsêca, Estela Kaminagakura, Ana Lia Anbinder, Kamilla Santos Alves, Maria Leticia de Almeida Lança, Sonia Sacsaquispe-Contreras, Karem Rodriguez Ibazetta, Roberto Gerber-Mora, Saray Aranda Romo, Francisco Javier Tejeda Nava, Karina Cordero-Torres, Ricardo Moreno Silva, Wilfredo Gonzalez-Arriagada, Raiza Toro, Felipe Martins Silveira, Natalia Gonzalez, Pablo Agustin Vargas, Alan Roger Santos-Silva, Ronell Bologna-Molina, Mariana Villarroel-Dorrego, Benjamin Martinez, Eduardo Piemonte

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objective: To determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America. Methods: A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential-OSCC versus OSCC-de novo (OSCC-dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t-test, and qualitative variables with chi-square. Results: In total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC-dn, while s-OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD. Conclusions: In Latin America, OSCC-dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.

Original language	English
Pages (from-to)	2965-2984
Number of pages	20
Journal	Oral Diseases
Volume	30
Issue number	5
DOIs	https://doi.org/10.1111/odi.14778
State	Published - 25 Oct 2023

Bibliographical note

Publisher Copyright:
© 2023 Wiley Periodicals LLC.

Keywords

Latin America
leukoplakia
oral cancer
oral potentially malignant disorders
oral squamous cell carcinoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/odi.14778

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Gilligan, G., Panico, R., Lazos, J., Morelatto, R., Belardinelli, P., Criscuolo, I., Bolesina, N., Molina Ávila, I., Pimentel Solá, JM., Rivarola, E., Morgante, M. J., Ingrassia Tonelli, ME., Gimenez, J., Doratti, P., Werner, LC., Prado-Ribeiro, A. C., Brandão, T. B., Vechiato-Filho, A. J., Cuzzullin, M. C., ... Piemonte, E. (2023). Oral squamous cell carcinomas and oral potentially malignant disorders: a Latin American study. Oral Diseases, 30(5), 2965-2984. https://doi.org/10.1111/odi.14778

@article{b98b3b2cbfdb4c939f17f8a2e346494d,

title = "Oral squamous cell carcinomas and oral potentially malignant disorders: a Latin American study",

abstract = "Objective: To determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America. Methods: A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential-OSCC versus OSCC-de novo (OSCC-dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t-test, and qualitative variables with chi-square. Results: In total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC-dn, while s-OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD. Conclusions: In Latin America, OSCC-dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.",

keywords = "Latin America, leukoplakia, oral cancer, oral potentially malignant disorders, oral squamous cell carcinoma",

author = "Gerardo Gilligan and Ren{\'e} Panico and Jer{\'o}nimo Lazos and Rosana Morelatto and Paola Belardinelli and Ines Criscuolo and Nicolas Bolesina and Ignacio Molina {\'A}vila and Juan Martin Pimentel Sol{\'a} and Emilce Rivarola and Morgante, {Maria Jimena} and Maria Eugenia Ingrassia Tonelli and Javier Gimenez and Pablo Doratti and Laura Cecilia Werner and Prado-Ribeiro, {Ana Carolina} and Brand{\~a}o, {Thais Bianca} and Vechiato-Filho, {Aljomar Jose} and Cuzzullin, {Maria Claudia} and Cristina Saldivia-Siracusa and Lopes, {Marcio Ajudarte} and Michelle Agostini and Roma{\~n}ach, {Mario Jos{\'e}} and Aline Corr{\^e}a Abrah{\~a}o and Fons{\^e}ca, {Thamyres Campos} and Estela Kaminagakura and Anbinder, {Ana Lia} and Kamilla Santos Alves and {de Almeida Lan{\c c}a}, {Maria Leticia} and Sonia Sacsaquispe-Contreras and Karem Rodriguez Ibazetta and Roberto Gerber-Mora and Saray Aranda Romo and Tejeda Nava, {Francisco Javier} and Karina Cordero-Torres and Ricardo Moreno Silva and Wilfredo Gonzalez-Arriagada and Raiza Toro and Felipe Martins Silveira and Natalia Gonzalez and Vargas, {Pablo Agustin} and Alan Roger Santos-Silva and Ronell Bologna-Molina and Mariana Villarroel-Dorrego and Benjamin Martinez and Eduardo Piemonte",

note = "Publisher Copyright: {\textcopyright} 2023 Wiley Periodicals LLC.",

year = "2023",

month = oct,

day = "25",

doi = "10.1111/odi.14778",

language = "English",

volume = "30",

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Gilligan, G, Panico, R, Lazos, J, Morelatto, R, Belardinelli, P, Criscuolo, I, Bolesina, N, Molina Ávila, I, Pimentel Solá, JM, Rivarola, E, Morgante, MJ, Ingrassia Tonelli, ME, Gimenez, J, Doratti, P, Werner, LC, Prado-Ribeiro, AC, Brandão, TB, Vechiato-Filho, AJ, Cuzzullin, MC, Saldivia-Siracusa, C, Lopes, MA, Agostini, M, Romañach, MJ, Abrahão, AC, Fonsêca, TC, Kaminagakura, E, Anbinder, AL, Santos Alves, K, de Almeida Lança, ML, Sacsaquispe-Contreras, S, Rodriguez Ibazetta, K, Gerber-Mora, R, Aranda Romo, S, Tejeda Nava, FJ, Cordero-Torres, K, Moreno Silva, R, Gonzalez-Arriagada, W, Toro, R, Silveira, FM, Gonzalez, N, Vargas, PA, Santos-Silva, AR, Bologna-Molina, R, Villarroel-Dorrego, M, Martinez, B & Piemonte, E 2023, 'Oral squamous cell carcinomas and oral potentially malignant disorders: a Latin American study', Oral Diseases, vol. 30, no. 5, pp. 2965-2984. https://doi.org/10.1111/odi.14778

TY - JOUR

T1 - Oral squamous cell carcinomas and oral potentially malignant disorders

T2 - a Latin American study

AU - Gilligan, Gerardo

AU - Panico, René

AU - Lazos, Jerónimo

AU - Morelatto, Rosana

AU - Belardinelli, Paola

AU - Criscuolo, Ines

AU - Bolesina, Nicolas

AU - Molina Ávila, Ignacio

AU - Pimentel Solá, Juan Martin

AU - Rivarola, Emilce

AU - Morgante, Maria Jimena

AU - Ingrassia Tonelli, Maria Eugenia

AU - Gimenez, Javier

AU - Doratti, Pablo

AU - Werner, Laura Cecilia

AU - Prado-Ribeiro, Ana Carolina

AU - Brandão, Thais Bianca

AU - Vechiato-Filho, Aljomar Jose

AU - Cuzzullin, Maria Claudia

AU - Saldivia-Siracusa, Cristina

AU - Lopes, Marcio Ajudarte

AU - Agostini, Michelle

AU - Romañach, Mario José

AU - Abrahão, Aline Corrêa

AU - Fonsêca, Thamyres Campos

AU - Kaminagakura, Estela

AU - Anbinder, Ana Lia

AU - Santos Alves, Kamilla

AU - de Almeida Lança, Maria Leticia

AU - Sacsaquispe-Contreras, Sonia

AU - Rodriguez Ibazetta, Karem

AU - Gerber-Mora, Roberto

AU - Aranda Romo, Saray

AU - Tejeda Nava, Francisco Javier

AU - Cordero-Torres, Karina

AU - Moreno Silva, Ricardo

AU - Gonzalez-Arriagada, Wilfredo

AU - Toro, Raiza

AU - Silveira, Felipe Martins

AU - Gonzalez, Natalia

AU - Vargas, Pablo Agustin

AU - Santos-Silva, Alan Roger

AU - Bologna-Molina, Ronell

AU - Villarroel-Dorrego, Mariana

AU - Martinez, Benjamin

AU - Piemonte, Eduardo

PY - 2023/10/25

Y1 - 2023/10/25

N2 - Objective: To determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America. Methods: A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential-OSCC versus OSCC-de novo (OSCC-dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t-test, and qualitative variables with chi-square. Results: In total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC-dn, while s-OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD. Conclusions: In Latin America, OSCC-dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.

AB - Objective: To determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America. Methods: A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential-OSCC versus OSCC-de novo (OSCC-dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t-test, and qualitative variables with chi-square. Results: In total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC-dn, while s-OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD. Conclusions: In Latin America, OSCC-dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.

KW - Latin America

KW - leukoplakia

KW - oral cancer

KW - oral potentially malignant disorders

KW - oral squamous cell carcinoma

UR - http://www.scopus.com/inward/record.url?scp=85174586825&partnerID=8YFLogxK

U2 - 10.1111/odi.14778

DO - 10.1111/odi.14778

M3 - Article

AN - SCOPUS:85174586825

SN - 1354-523X

VL - 30

SP - 2965

EP - 2984

JO - Oral Diseases

JF - Oral Diseases

IS - 5

ER -

Oral squamous cell carcinomas and oral potentially malignant disorders: a Latin American study

Abstract

Bibliographical note

Keywords

UN SDGs

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