Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets

César Rivera, Mariangela Fernanda Crisóstomo, Carolina Peña, Paulina González-Díaz, Wilfredo Alejandro González-Arriagada

Research output: Contribution to journalArticlepeer-review

Abstract

Today, we face difficulty in generating new hypotheses and understanding oral lichen planus due to the large amount of biomedical information available. In this research, we have used an integrated bioinformatics approach assimilating information from data mining, gene ontologies, protein–protein interaction and network analysis to predict candidate genes related to oral lichen planus. A detailed pathway analysis led us to propose two promising therapeutic targets: the stromal cell derived factor 1 (CXCL12) and the C-X-C type 4 chemokine receptor (CXCR4). We further validated our predictions and found that CXCR4 was upregulated in all oral lichen planus tissue samples. Our bioinformatics data cumulatively support the pathological role of chemokines and chemokine receptors in oral lichen planus. From a clinical perspective, we suggest a drug (plerixafor) and two therapeutic targets for future research.

Original languageEnglish
Article number5454
JournalScientific Reports
Volume10
Issue number1
DOIs
StatePublished - 1 Dec 2020
Externally publishedYes

Bibliographical note

Funding Information:
Funding was provided by Fondo Nacional de Desarrollo Científico y Tecnológico (Fondecyt; grant no. 11180170) and Red Estatal de Odontología (grant no. REO19–012).

Publisher Copyright:
© 2020, The Author(s).

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