Nuclear DNA replication and repair in parasites of the genus Leishmania: Exploiting differences to develop innovative therapeutic approaches

Graciela Uzcanga, Eliana Lara, Fernanda Gutiérrez, Doyle Beaty, Timo Beske, Rommy Teran, Juan Carlos Navarro, Philippe Pasero, Washington Benítez, Ana Poveda*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Leishmaniasis is a common tropical disease that affects mainly poor people in underdeveloped and developing countries. This largely neglected infection is caused by Leishmania spp, a parasite from the Trypanosomatidae family. This parasitic disease has different clinical manifestations, ranging from localized cutaneous to more harmful visceral forms. The main limitations of the current treatments are their high cost, toxicity, lack of specificity, and long duration. Efforts to improve treatments are necessary to deal with this infectious disease. Many approved drugs to combat diseases as diverse as cancer, bacterial, or viral infections take advantage of specific features of the causing agent or of the disease. Recent evidence indicates that the specific characteristics of the Trypanosomatidae replication and repair machineries could be used as possible targets for the development of new treatments. Here, we review in detail the molecular mechanisms of DNA replication and repair regulation in trypanosomatids of the genus Leishmania and the drugs that could be useful against this disease.

Original languageEnglish
Pages (from-to)156-177
Number of pages22
JournalCritical Reviews in Microbiology
Volume43
Issue number2
DOIs
StatePublished - 4 Mar 2017
Externally publishedYes

Bibliographical note

Funding Information:
The authors thank M. Fors, the Ecuadorian Ministerio de Salud P?blica-MSP, and Agencia de Regulaci?n y Control Sanitario-ARCSA for facilitating administrative tasks and authorization of the needed permissions. The authors also thank E. Andermarcher for edition work, J. L. Ram?rez for critical Reading, and the Centro Internacional de Zoonosis staff for their support. The work in the Poveda Laboratory is funded by Universidad Central del Ecuador, Direcci?n General de Investigaci?n y Posgrado [Project #21]. Also employment of E. L., F. G., and D. B. was supported for the same project. G. U. and J. C. N. were fellows of the Prometeo program (SENESCYT) [10.13039/501100004299].

Publisher Copyright:
© 2016 Universidad Central del Ecuador. Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • DNA damage
  • DNA replication
  • drugs
  • genome stability
  • Leishmania

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