Lymphocyte b and th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants.

Alejandra Chaparro; Antonio Sanz; Andrei Wolnitzky; Ornella Realini; María José Bendek; Daniel Betancur; Daniela Albers; Víctor Beltrán

doi:10.17126/JORALRES.2020.029

Lymphocyte b and th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants.

Alejandra Chaparro^*, Antonio Sanz, Andrei Wolnitzky, Ornella Realini, María José Bendek, Daniel Betancur, Daniela Albers, Víctor Beltrán

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Peri-implantitis is one of the leading causes of implant failure and loss, and its early diagnosis is not currently feasible due to the low sensitivity of currents methods. In the current exploratory cross-sectional study, we explored the diagnostic potential of lymphocyte B and Th17-chemotactic cytokine levels in peri-implant crevicular fluid (PICF) in 54 patients with healthy, peri-mucositis, or peri-implantitis implants. Peri-implant crevicular fluid was collected, and the levels of the molecules under study were quantified by Luminex assay. The concentrations of CCL-20 MIP-3 alpha, BAFF/BLYS, RANKL and OPG concentration in PICF were analyzed in the context of patient and clinical variables (smoking status, history of periodontitis, periodontal diagnosis, implant survival, suppuration, bleeding on probing, periodontal probing depth, clinical attachment level, mean of implant probing depth, and plaque index). Patients with peri-implantitis, appear to have an overregulation of the RANKL/BAFF-BLyS axis. This phenomenon needs to be investigated in depth in further studies with a larger sample size.

Translated title of the contribution	Niveles de citoquinas quimiotácticas de linfocitos by th17 en el fluido crevicular periimplantario de pacientes con implantes sanos, perimucositis y periimplantitis.
Original language	English
Pages (from-to)	20-25
Number of pages	6
Journal	Journal of Oral Research
Volume	2020
Issue number	Special Issue 1
DOIs	https://doi.org/10.17126/JORALRES.2020.029
State	Published - 1 Jul 2020

Bibliographical note

Funding Information:
Acknowledgements: This study was funded by Proyecto RE?I170658, CONICYT-Chile and the Innovation Contest "Inicia Tu Idea Universidad de La Frontera-Universidad de Los Andes” resolution code No. 0468.

Funding Information:
This study was funded by Proyecto REDI170658, CONICYT-Chile and the Innovation Contest "Inicia Tu Idea Universidad de La Frontera-Universidad de Los Andes? resolution code No. 0468.

Publisher Copyright:
© 2020, Universidad de Concepcion. All rights reserved.

Keywords

Chemokine ccl20
Enzyme-linked immunosorbent assay
Gingival crevicular fluid
Mucositis
Peri-implantitis
RANK ligand

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10.17126/JORALRES.2020.029

Cite this

Chaparro, A., Sanz, A., Wolnitzky, A., Realini, O., Bendek, M. J., Betancur, D., Albers, D., & Beltrán, V. (2020). Lymphocyte b and th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants. Journal of Oral Research, 2020(Special Issue 1), 20-25. https://doi.org/10.17126/JORALRES.2020.029

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title = "Lymphocyte b and th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants.",

abstract = "Peri-implantitis is one of the leading causes of implant failure and loss, and its early diagnosis is not currently feasible due to the low sensitivity of currents methods. In the current exploratory cross-sectional study, we explored the diagnostic potential of lymphocyte B and Th17-chemotactic cytokine levels in peri-implant crevicular fluid (PICF) in 54 patients with healthy, peri-mucositis, or peri-implantitis implants. Peri-implant crevicular fluid was collected, and the levels of the molecules under study were quantified by Luminex assay. The concentrations of CCL-20 MIP-3 alpha, BAFF/BLYS, RANKL and OPG concentration in PICF were analyzed in the context of patient and clinical variables (smoking status, history of periodontitis, periodontal diagnosis, implant survival, suppuration, bleeding on probing, periodontal probing depth, clinical attachment level, mean of implant probing depth, and plaque index). Patients with peri-implantitis, appear to have an overregulation of the RANKL/BAFF-BLyS axis. This phenomenon needs to be investigated in depth in further studies with a larger sample size.",

keywords = "Chemokine ccl20, Enzyme-linked immunosorbent assay, Gingival crevicular fluid, Mucositis, Peri-implantitis, RANK ligand",

author = "Alejandra Chaparro and Antonio Sanz and Andrei Wolnitzky and Ornella Realini and Bendek, {Mar{\'i}a Jos{\'e}} and Daniel Betancur and Daniela Albers and V{\'i}ctor Beltr{\'a}n",

note = "Funding Information: Acknowledgements: This study was funded by Proyecto RE?I170658, CONICYT-Chile and the Innovation Contest {"}Inicia Tu Idea Universidad de La Frontera-Universidad de Los Andes” resolution code No. 0468. Funding Information: This study was funded by Proyecto REDI170658, CONICYT-Chile and the Innovation Contest {"}Inicia Tu Idea Universidad de La Frontera-Universidad de Los Andes? resolution code No. 0468. Publisher Copyright: {\textcopyright} 2020, Universidad de Concepcion. All rights reserved.",

year = "2020",

month = jul,

day = "1",

doi = "10.17126/JORALRES.2020.029",

language = "English",

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Chaparro, A, Sanz, A, Wolnitzky, A, Realini, O, Bendek, MJ, Betancur, D, Albers, D & Beltrán, V 2020, 'Lymphocyte b and th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants.', Journal of Oral Research, vol. 2020, no. Special Issue 1, pp. 20-25. https://doi.org/10.17126/JORALRES.2020.029

Lymphocyte b and th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants. / Chaparro, Alejandra; Sanz, Antonio; Wolnitzky, Andrei et al.
In: Journal of Oral Research, Vol. 2020, No. Special Issue 1, 01.07.2020, p. 20-25.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Lymphocyte b and th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants.

AU - Chaparro, Alejandra

AU - Sanz, Antonio

AU - Wolnitzky, Andrei

AU - Realini, Ornella

AU - Bendek, María José

AU - Betancur, Daniel

AU - Albers, Daniela

AU - Beltrán, Víctor

N1 - Funding Information: Acknowledgements: This study was funded by Proyecto RE?I170658, CONICYT-Chile and the Innovation Contest "Inicia Tu Idea Universidad de La Frontera-Universidad de Los Andes” resolution code No. 0468. Funding Information: This study was funded by Proyecto REDI170658, CONICYT-Chile and the Innovation Contest "Inicia Tu Idea Universidad de La Frontera-Universidad de Los Andes? resolution code No. 0468. Publisher Copyright: © 2020, Universidad de Concepcion. All rights reserved.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Peri-implantitis is one of the leading causes of implant failure and loss, and its early diagnosis is not currently feasible due to the low sensitivity of currents methods. In the current exploratory cross-sectional study, we explored the diagnostic potential of lymphocyte B and Th17-chemotactic cytokine levels in peri-implant crevicular fluid (PICF) in 54 patients with healthy, peri-mucositis, or peri-implantitis implants. Peri-implant crevicular fluid was collected, and the levels of the molecules under study were quantified by Luminex assay. The concentrations of CCL-20 MIP-3 alpha, BAFF/BLYS, RANKL and OPG concentration in PICF were analyzed in the context of patient and clinical variables (smoking status, history of periodontitis, periodontal diagnosis, implant survival, suppuration, bleeding on probing, periodontal probing depth, clinical attachment level, mean of implant probing depth, and plaque index). Patients with peri-implantitis, appear to have an overregulation of the RANKL/BAFF-BLyS axis. This phenomenon needs to be investigated in depth in further studies with a larger sample size.

AB - Peri-implantitis is one of the leading causes of implant failure and loss, and its early diagnosis is not currently feasible due to the low sensitivity of currents methods. In the current exploratory cross-sectional study, we explored the diagnostic potential of lymphocyte B and Th17-chemotactic cytokine levels in peri-implant crevicular fluid (PICF) in 54 patients with healthy, peri-mucositis, or peri-implantitis implants. Peri-implant crevicular fluid was collected, and the levels of the molecules under study were quantified by Luminex assay. The concentrations of CCL-20 MIP-3 alpha, BAFF/BLYS, RANKL and OPG concentration in PICF were analyzed in the context of patient and clinical variables (smoking status, history of periodontitis, periodontal diagnosis, implant survival, suppuration, bleeding on probing, periodontal probing depth, clinical attachment level, mean of implant probing depth, and plaque index). Patients with peri-implantitis, appear to have an overregulation of the RANKL/BAFF-BLyS axis. This phenomenon needs to be investigated in depth in further studies with a larger sample size.

KW - Chemokine ccl20

KW - Enzyme-linked immunosorbent assay

KW - Gingival crevicular fluid

KW - Mucositis

KW - Peri-implantitis

KW - RANK ligand

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U2 - 10.17126/JORALRES.2020.029

DO - 10.17126/JORALRES.2020.029

M3 - Article

AN - SCOPUS:85094667593

SN - 0719-2460

VL - 2020

SP - 20

EP - 25

JO - Journal of Oral Research

JF - Journal of Oral Research

IS - Special Issue 1

ER -

Lymphocyte b and th17 chemotactic cytokine levels in peri-implant crevicular fluid of patients with healthy, peri-mucositis, and peri-implantitis implants.

Abstract

Bibliographical note

Keywords

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