Abstract
The present invention offers an effective alternative method for treating neurological disorders, preferably those induced by a nerve injury or by a neurodegenerative process. The present invention is the first to show that a substantially pure population of exosomes derived from menstrual stem cells (MenSCs) have the capacity to increase the neuritic outgrowth of cortical and sensory neurons. The present invention shows that a substantially pure population of MenSCs-derived exosomes increases the length of the longest neurite and the ramification pattern of cortical neurons. MenSc and bone marrow stem cells (BMSCs) also promote the neuritic growth of neurons from the dorsal route ganglia. Overall, the invention offers a promising alternative method to treat neurological disorders involving the loss of nerve tissues. Since it is principally composed of exosomes produced by the stem cells present in menstrual fluid, the invention provides an ease access and repeated sampling in a non-invasive manner.
| Original language | American English |
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| Patent number | WO2017064688 |
| IPC | C12N 5/ 079 A I |
| Priority date | 15/10/15 |
| State | Published - 20 Apr 2017 |