Nasal carriage of Streptococcus pneumoniae in elderly subjects according to vaccination status

Rogelio Altuzarra Hernáez, M. Teresa Valenzuela B, Olivia Trucco A, Jaime Inostroza S, Paulo Granata S, José Fleiderman V

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4 Scopus citations


Background: S pneumoniae is the main cause of community-acquired pneumonia in the elderly, group that concentrates 95% of deaths. Aim: To assess the prevalence of nasal carriage of S pneumoniae in institutionalized elderly patients. Material and methods: One hundred eighteen institutionalized subjects aged over 60 years (65 males) were enrolled. Since they were also participating in a controlled protocol related to the immunogenicity of an anti-pneumococcal vaccine, our investigation was also blind and randomized. According to randomization, they received pneumococcal or tetanic vaccine. Nasal swab cultures were taken at the beginning of the trial and two months after vaccination. According to recommended methods, we identified S pneumoniae, the serotypes and their antimicrobial susceptibility. Results: In the first nasal sample, 16% of subjects were positive for S pneumoniae. The second sample was positive in 12%. Of the 33 isolated serotypes, 9.1% demonstrated intermediate resistance to penicillin and 3.3% were resistant to chloramphenicol. Conclusions: The study demonstrated a greater percentage of colonized patients than in the general population. The isolated serotypes are the same that cause invasive diseases in this age group, according to data of the Institute of Public Health of Chile. There were no differences in the percentage of colonization between subjects vaccinated against S pneumoniae and control groups, after two months of follow up. Isolated strains had a low resistance to penicillin. High level resistance was not observed.
Original languageAmerican English
Pages (from-to)160-166
Number of pages7
JournalRevista Medica de Chile
Issue number2
StatePublished - 1 Jan 2007
Externally publishedYes


  • Aged
  • Pneumococcal vaccines
  • Streptococcus pneumoniae

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