Nanofilled/nanohybrid and hybrid resin-based composite in patients with direct restorations in posterior teeth: A systematic review and meta-analysis

Bianca Medeiros Maran, Juliana Larocca de Geus, Mario Felipe Gutiérrez, Siegward Heintze, Chane Tardem, Marcos O. Barceleiro, Alessandra Reis, Alessandro D. Loguercio*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Objective: A systematic review and a meta-analysis were performed to answer the following research question: Are there differences in the color match and surface texture of nanofilled/nanohybrid and hybrid composite in patients with direct posterior restorations? Data: Randomized clinical trials that compared nanofilled/nanohybrid and hybrid composite in direct restoration in posterior teeth were included. For the analysis of the bias the risk of bias tool (RoB) was used. Meta-analyses of different pairs (nanofilled vs. hybrid and nanohybrid vs. hybrid composite) were conducted for surface texture and color match and other secondary outcomes at different follow-ups, using a random effects model. Heterogeneity was assessed with the Cochran Q test and I2 statistics. GRADE was used to assess the quality of the evidence. Sources: A search was performed in PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library and SIGLE, without restrictions. IADR abstracts (2001–2019), unpublished and ongoing trials registries, dissertations and theses were also searched. Study selection: 28 studies remained. No study was considered to be at low RoB; four studies were judged to have high RoB, and the remaining were judged to have unclear RoB. Results: For the primary and secondary outcomes variables no significant differences were detected between nanofilled/nanohybrid restorations and hybrid composite restorations in any of the study follow-ups (p > 0.08). The body of evidence for surface texture and color match was classified as moderate or low. Conclusion: No evidence of difference was found between nanofilled/nanohybrid and hybrid composite in any of the clinical parameters evaluated.

Original languageEnglish
Article number103407
JournalJournal of Dentistry
StatePublished - Aug 2020

Bibliographical note

Funding Information:
This study is part of the presentation of Prof. Dr. Alessandro D. Loguercio during the Annual meeting of World Dental Federation (FDI), Buenos Aires, Argentine (2018) in the Symposium: “Nanoparticles in Dentistry – Risks and Promises”, together with Prof. Dr. Alexander Besinis and Prof. Gottfried Schmalz and coordinated by Prof. Dr. Reinhard Hickel. This study was partially supported by the National Council for Scientific and Technological Development (CNPq) under grants 303332/2017-4 and 308286/2019-7 and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001.

Publisher Copyright:
© 2020 Elsevier Ltd


  • Dental restoration
  • Meta-analysis
  • Nanotechnology
  • Permanent
  • Systematic review


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