TY - JOUR
T1 - NanoBubble-Mediated Oxygenation
T2 - elucidating the Underlying Molecular Mechanisms in Hypoxia and Mitochondrial-Related Pathologies
AU - Viafara Garcia, Sergio M.
AU - Khan, Muhammad Saad
AU - Haidar, Ziyad S.
AU - Acevedo Cox, Juan Pablo
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/11/30
Y1 - 2023/11/30
N2 - Worldwide, hypoxia-related conditions, including cancer, COVID-19, and neuro-degenerative diseases, often lead to multi-organ failure and significant mortality. Oxygen, crucial for cellular function, becomes scarce as levels drop below 10 mmHg (<2% O 2), triggering mitochondrial dysregulation and activating hypoxia-induced factors (HiFs). Herein, oxygen nanobubbles (OnB), an emerging versatile oxygen delivery platform, offer a novel approach to address hypoxia-related pathologies. This review explores OnB oxygen delivery strategies and systems, including diffusion, ultrasound, photodynamic, and pH-responsive nanobubbles. It delves into the nanoscale mechanisms of OnB, elucidating their role in mitochondrial metabolism (TFAM, PGC1alpha), hypoxic responses (HiF-1alpha), and their interplay in chronic pathologies including cancer and neurodegenerative disorders, amongst others. By understanding these dynamics and underlying mechanisms, this article aims to contribute to our accruing knowledge of OnB and the developing potential in ameliorating hypoxia- and metabolic stress-related conditions and fostering innovative therapies.
AB - Worldwide, hypoxia-related conditions, including cancer, COVID-19, and neuro-degenerative diseases, often lead to multi-organ failure and significant mortality. Oxygen, crucial for cellular function, becomes scarce as levels drop below 10 mmHg (<2% O 2), triggering mitochondrial dysregulation and activating hypoxia-induced factors (HiFs). Herein, oxygen nanobubbles (OnB), an emerging versatile oxygen delivery platform, offer a novel approach to address hypoxia-related pathologies. This review explores OnB oxygen delivery strategies and systems, including diffusion, ultrasound, photodynamic, and pH-responsive nanobubbles. It delves into the nanoscale mechanisms of OnB, elucidating their role in mitochondrial metabolism (TFAM, PGC1alpha), hypoxic responses (HiF-1alpha), and their interplay in chronic pathologies including cancer and neurodegenerative disorders, amongst others. By understanding these dynamics and underlying mechanisms, this article aims to contribute to our accruing knowledge of OnB and the developing potential in ameliorating hypoxia- and metabolic stress-related conditions and fostering innovative therapies.
KW - cancer
KW - drug delivery
KW - hypoxia
KW - innovation
KW - metabolism
KW - mitochondria
KW - molecular
KW - nanobubbles
KW - oxygen
KW - stress
UR - http://www.scopus.com/inward/record.url?scp=85178886224&partnerID=8YFLogxK
U2 - 10.20944/preprints202310.0962.v1
DO - 10.20944/preprints202310.0962.v1
M3 - Review article
C2 - 38063756
SN - 2079-4991
VL - 13
SP - 1
EP - 30
JO - Nanomaterials
JF - Nanomaterials
IS - 23
M1 - 3060
ER -
