TY - JOUR
T1 - Morphologic and functional determinants of primordial and primary follicles in the monkey ovary
AU - Busso, Dolores
N1 - Funding Information:
We thank Pr Aaron JW Hsueh for the gift of the GDF-9 antibody. This work was supported by grants from Serono France.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2000/5/25
Y1 - 2000/5/25
N2 - In mammals, the mechanisms triggering initiation of follicular growth remain largely unknown. The present study constitutes an attempt to relate morphological and functional changes occuring in follicles at the time of transition from the nongrowing to the early growing stage. The population of very small follicles, including both nongrowing and early growing follicles, has been studied in fetal and adult monkey (Macaca fascicularis). Counts of these follicles and immunohistochemical analyses of their content in various intraovarian peptides led to the conclusion that initiation is probably not similar, on a quantitative as well as a qualitative point of view, in the fetal and in the adult ovary. In addition to the recently evidenced stimulatory role of the stem cell factor (SCF) in rats, activation of a nongrowing follicle might imply an arrest in the production of inhibiting factors, such as the transforming growth factor-β2 (TGF-β2), occuring simultaneously with the production of stimulatory factors, such as the transforming growth factor-alpha (TGFα). (C) 2000 Published by Elsevier Science Ireland Ltd.
AB - In mammals, the mechanisms triggering initiation of follicular growth remain largely unknown. The present study constitutes an attempt to relate morphological and functional changes occuring in follicles at the time of transition from the nongrowing to the early growing stage. The population of very small follicles, including both nongrowing and early growing follicles, has been studied in fetal and adult monkey (Macaca fascicularis). Counts of these follicles and immunohistochemical analyses of their content in various intraovarian peptides led to the conclusion that initiation is probably not similar, on a quantitative as well as a qualitative point of view, in the fetal and in the adult ovary. In addition to the recently evidenced stimulatory role of the stem cell factor (SCF) in rats, activation of a nongrowing follicle might imply an arrest in the production of inhibiting factors, such as the transforming growth factor-β2 (TGF-β2), occuring simultaneously with the production of stimulatory factors, such as the transforming growth factor-alpha (TGFα). (C) 2000 Published by Elsevier Science Ireland Ltd.
KW - C-kit receptor
KW - Epidermal growth factor system
KW - Growth differentiation factor 9
KW - Monkey ovary (fetus, adult)
KW - Primordial follicles
KW - Stem cell factor
KW - Transforming growth factor-βs
UR - http://www.scopus.com/inward/record.url?scp=0034713154&partnerID=8YFLogxK
U2 - 10.1016/S0303-7207(00)00220-3
DO - 10.1016/S0303-7207(00)00220-3
M3 - Article
C2 - 10963871
AN - SCOPUS:0034713154
VL - 163
SP - 33
EP - 42
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 1-2
ER -