Monitoring Changes in Oxygen Muscle during Exercise with High-Flow Nasal Cannula Using Wearable NIRS Biosensors

Felipe Contreras-Briceño*, Maximiliano Espinosa-Ramírez, Augusta Rivera-Greene, Camila Guerra-Venegas, Antonia Lungenstrass-Poulsen, Victoria Villagra-Reyes, Raúl Caulier-Cisterna, Oscar F. Araneda, Ginés Viscor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Exercise increases the cost of breathing (COB) due to increased lung ventilation ((Formula presented.) E), inducing respiratory muscles deoxygenation ((Formula presented.) SmO2), while the increase in workload implies (Formula presented.) SmO2 in locomotor muscles. This phenomenon has been proposed as a leading cause of exercise intolerance, especially in clinical contexts. The use of high-flow nasal cannula (HFNC) during exercise routines in rehabilitation programs has gained significant interest because it is proposed as a therapeutic intervention for reducing symptoms associated with exercise intolerance, such as fatigue and dyspnea, assuming that HFNC could reduce exercise-induced (Formula presented.) SmO2. SmO2 can be detected using optical wearable devices provided by near-infrared spectroscopy (NIRS) technology, which measures the changes in the amount of oxygen bound to chromophores (e.g., hemoglobin, myoglobin, cytochrome oxidase) at the target tissue level. We tested in a study with a cross-over design whether the muscular desaturation of m.vastus lateralis and m.intercostales during a high-intensity constant-load exercise can be reduced when it was supported with HFNC in non-physically active adults. Eighteen participants (nine women; age: 22 ± 2 years, weight: 65.1 ± 11.2 kg, height: 173.0 ± 5.8 cm, BMI: 21.6 ± 2.8 kg·m−2) were evaluated in a cycle ergometer (15 min, 70% maximum watts achieved in ergospirometry ((Formula presented.) O2-peak)) breathing spontaneously (control, CTRL) or with HFNC support (HFNC; 50 L·min−1, fiO2: 21%, 30 °C), separated by seven days in randomized order. Two-way ANOVA tests analyzed the (Formula presented.) SmO2 (m.intercostales and m.vastus lateralis), and changes in (Formula presented.) E and (Formula presented.) SmO2· (Formula presented.) E−1. Dyspnea, leg fatigue, and effort level (RPE) were compared between trials by the Wilcoxon matched-paired signed rank test. We found that the interaction of factors (trial × exercise-time) was significant in (Formula presented.) SmO2-m.intercostales, (Formula presented.) E, and ((Formula presented.) SmO2-m.intercostales)/ (Formula presented.) E (p < 0.05, all) but not in (Formula presented.) SmO2-m.vastus lateralis. (Formula presented.) SmO2-m.intercostales was more pronounced in CTRL during exercise since 5′ (p < 0.05). Hyperventilation was higher in CTRL since 10′ (p < 0.05). The (Formula presented.) SmO2· (Formula presented.) E−1 decreased during exercise, being lowest in CTRL since 5′. Lower dyspnea was reported in HFNC, with no differences in leg fatigue and RPE. We concluded that wearable optical biosensors documented the beneficial effect of HFNC in COB due to lower respiratory (Formula presented.) SmO2 induced by exercise. We suggest incorporating NIRS devices in rehabilitation programs to monitor physiological changes that can support the clinical impact of the therapeutic intervention implemented.

Original languageEnglish
Article number985
JournalBiosensors
Volume13
Issue number11
DOIs
StatePublished - Nov 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • exercise
  • near-infrared spectroscopy
  • optical
  • rehabilitation
  • wearable

Fingerprint

Dive into the research topics of 'Monitoring Changes in Oxygen Muscle during Exercise with High-Flow Nasal Cannula Using Wearable NIRS Biosensors'. Together they form a unique fingerprint.

Cite this