Molecular mechanisms involved in mammalian gamete fusion

Patricia S. Cuasnicú, Diego A. Ellerman, Debora J. Cohen, Dolores Busso, Mauro M. Morgenfeld, Vanina G. Da Ros

Research output: Contribution to journalScientific reviewpeer-review

34 Scopus citations

Abstract

Fusion between gametes is a key event in the fertilization process involving the interaction of specific domains of the sperm and egg plasma membranes. During recent years, efforts have been made toward the identification of the specific molecular components involved in this event. The present work will focus on the best characterized candidates for mediating gamete membrane fusion in mammals. These molecules include members of the ADAM (a disintegrin and a metalloprotease domain) family, i.e., testicular proteins fertilin α, fertilin β, and cyritestin, which are thought to interact with integrins in the egg plasma membrane through their disintegrin domains, and a member of the cysteine-rich secretory proteins (CRISP) family, i.e., epididymal protein DE, which participates in an event subsequent to sperm-egg binding and leading to fusion through specific complementary sites localized on the fusogenic area of the egg surface. The identification and characterization of these molecules will contribute not only to a better understanding of the molecular mechanisms underlying mammalian sperm-egg fusion but also to the development of new methods for both fertility regulation and diagnosis and treatment of human infertility.
Original languageAmerican English
Pages (from-to)614-618
Number of pages5
JournalArchives of Medical Research
Volume32
Issue number6
DOIs
StatePublished - 1 Jan 2001
Externally publishedYes

Keywords

  • Cyritestin
  • Fertilin
  • Fertilization
  • Sperm-egg binding

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