Abstract
Background: The aim of this feasibility study was to investigate the concentration level of CCL-20/MIP-3α, BAFF/BLyS, IL-23, RANKL, and Osteoprotegerin in the Peri-Implant Crevicular Fluid (PICF), from patients diagnosed with peri-implant mucositis and peri-implantitis, and to compare them with PICF from patients with healthy implants. Methods: Participants with at least one dental implant with healthy peri-implant tissues, peri-implant mucositis, or peri-implantitis were included. PICF was collected using paper strips from healthy and diseased peri-implant sites (n = 19). Biomarker levels were analyzed using a custom Multiplex ELISA Assay Kit. Results: In comparison to peri-implant health, the peri-implant mucositis group showed an increased concentration of CCL-20 MIP-3α, BAFF/BLyS, IL-23, RANKL, and Osteoprotegerin. The peri-implantitis group had the lowest median concentration of Osteoprotegerin (1963 ng/mL); this group had a similar concentration of RANKL (640.84 ng/mL) when compared to the peri-implant health group. BAFF/BLyS (17.06 ng/mL) showed the highest concentration in the peri-implantitis group. Conclusions: This feasibility study suggests that IL-23 and RANKL may help to elucidate the pathogenesis during the conversion from peri-implant health to peri-implantitis. Further research is required in BAFF/BLyS for the early diagnosis of peri-implantitis.
| Original language | English |
|---|---|
| Article number | 9802 |
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | International Journal of Molecular Sciences |
| Volume | 23 |
| Issue number | 17 |
| DOIs | |
| State | Published - 29 Aug 2022 |
Bibliographical note
Publisher Copyright:© 2022 by the authors.
Keywords
- Biomarkers/analysis
- Cross-Sectional Studies
- Dental Implants/adverse effects
- Gingival Crevicular Fluid
- Humans
- Interleukin-23
- Mucositis
- Osteoprotegerin/analysis
- Peri-Implantitis/diagnosis
- Pilot Projects