Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

G. Sydow-Plum; Z.S. Haidar; Y. Merhi; M. Tabrizian

doi:10.3390/ma1010025

Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

G. Sydow-Plum, Z.S. Haidar, Y. Merhi, M. Tabrizian^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Membrane-covered Express2TM Monorail® stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs.

Original language	English
Pages (from-to)	25-43
Number of pages	19
Journal	Materials
Volume	1
Issue number	1
DOIs	https://doi.org/10.3390/ma1010025
State	Published - Dec 2008
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

Keywords

Chitosan
Controlled drug release
Hyaluronic acid
Paclitaxel
Polyethylene oxide
Restenosis
Stent
Thrombogenecity

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10.3390/ma1010025

http://adsabs.harvard.edu/abs/2008Mate....1...25S

Cite this

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title = "Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies",

abstract = "Membrane-covered Express2TM Monorail{\textregistered} stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs. ",

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AU - Tabrizian, M.

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Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

Abstract

Bibliographical note

Keywords

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